L-NNA对大鼠脑缺血时脑组织含水量和乳酸含量的影响  

Effect of- N-nitro- L-arginine on Brain Edema and Lactate in Rats During Cerebral lschemia

作　　者：张洪[1] 慕容慎行[1] 刘友尧[2] 许国英[1] 吴秀丽[1] 

机构地区：[1]福建医科大学附属第一医院,省神经病学研究所福州350005 [2]福建医科大学生化教研室

出　　处：《海峡药学》2000年第2期21-22,共2页Strait Pharmaceutical Journal

摘　　要：研究 NOS抑制剂对大鼠脑缺血时脑组织含水量和乳酸含量的影响 ,用干湿质量法和酶法检测脑组织中含水量和乳酸含量。结果表明脑缺血 10 min,脑组织含水量和乳酸含量明显高于假手术组 (P<0 .0 1) ;预先给予 L- NNA(1m g· kg- 1 )可明显降低脑缺血 10 min时组织含水量和乳酸的含量 (P<0 .A study on the effect of nitric oxide synthase (NOS) inhibitor on brain edema and lactate in rats during cerebral ischemia was reported,Brain water contents and lactate were measured with percentage ratio of wet over dry tissue weight and LDH method The results showed that brain water content and lactate were significantly increased at 10min ischemia group compared with sham-operated group(P<0 01) Pretreated with L NNA(1mg·kg\+\{-1\})significantly decreased brain water content and lactate at 10min ischemia (P<0 05 or P<0 01)。

关 键 词：大鼠 脑缺血 脑水肿 乳酸 N-硝基在旋精氨酸 

分 类 号：R743.310.6[医药卫生—神经病学与精神病学] R742.7[医药卫生—临床医学]