A New Biselector Chiral Stationary Phase Derived from Tartaric Acid and Its Enantioseparation Evaluation  

作　　者：CHEN Wei ZHANG Juan LI Yingzhao BAI Zhengwu HUANG Shaohua 

机构地区：[1]Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology, Wuhan 430073, Hubei, China [2]Key Laboratory of Biodiesel of the Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China

出　　处：《Wuhan University Journal of Natural Sciences》2012年第5期383-390,共8页武汉大学学报（自然科学英文版）

基　　金：Supported by the National Natural Science Foundation of China (20675061 and 50973086);the Research Project of Department of Education of Hubei Province (Z20081501)

摘　　要：Two chiral selectors were synthesized from tartaric acid. The selectors were simultaneously immobilized on 3-aminopropyl silica gel to obtain a new biselector chiral stationary phase （CSP） in order to determine the influence of selector structure of biselector CSPs on the chiral recognition capability. For comparison, the single-selector CSP was also prepared. The biselector CSP shows an improved overall chiral recognition capability in comparison with the single-selector CSP. During the enantioseparation, temporary diastereoisomers are likely formed by complexation between a chiral analyte and the two selectors on the biselector CSP. The functional groups in the two selectors are complementary in electronic effect and/or in steric hindrance for the chiral recognition.Two chiral selectors were synthesized from tartaric acid. The selectors were simultaneously immobilized on 3-aminopropyl silica gel to obtain a new biselector chiral stationary phase （CSP） in order to determine the influence of selector structure of biselector CSPs on the chiral recognition capability. For comparison, the single-selector CSP was also prepared. The biselector CSP shows an improved overall chiral recognition capability in comparison with the single-selector CSP. During the enantioseparation, temporary diastereoisomers are likely formed by complexation between a chiral analyte and the two selectors on the biselector CSP. The functional groups in the two selectors are complementary in electronic effect and/or in steric hindrance for the chiral recognition.

关 键 词：biselector chiral stationary phase ENANTIOSEPARATION chiral recognition mechanism high-performance liquid chromatography 

分 类 号：O657.7[理学—分析化学]