脂联素受体在结直肠癌和结直肠腺瘤组织中表达  

Expression of adiponectin receptors R1 and R2 in colorectal carcinoma and colorectal adenoma

作　　者：宋敏[1] 畅婕[1,2] 孟宇[1] 李磊[1] 

机构地区：[1]郑州大学第一附属医院肿瘤内科,河南省郑州市450052 [2]郑州大学肿瘤病理学实验室,河南省郑州市450052

出　　处：《世界华人消化杂志》2012年第29期2845-2850,共6页World Chinese Journal of Digestology

摘　　要：目的:检测脂联素受体1(adiponectin receptors1,R1)和R2在人结直肠癌组织、腺瘤组织、癌旁组织中的表达情况与临床病理特征的关系及3种组织中R1和R2的关联性.方法:采用免疫组织化学SP法检测51例新鲜结直肠癌组织,42例结直肠腺瘤组织,35例癌旁组织中脂联素受体R1和R2的表达.结果:免疫组织化学结果显示R1在人结直肠癌组织中表达高于腺瘤组织(P=0.047),结直肠癌组织中表达高于癌旁组织(P=0.002),腺瘤组织中的表达高于癌旁组织(P=0.042).R2在人结直肠癌组织中表达高于腺瘤组织(P=0.035),结直肠癌组织中表达高于癌旁组织(P=0.002),腺瘤组织中表达高于癌旁组织(P=0.046).在3种组织中,R1与R2的表达无关联性(P>0.05).在51例结直肠癌组织中脂联素受体表达与分化程度、淋巴结转移、TNM分期相关(均P<0.05),与性别、年龄、肿瘤大小、组织学类型无明显相关(P>0.05).结论:脂联素受体在人结直肠癌组织、腺瘤组织、癌旁组织中普遍表达,且在结直肠癌组织中的表达最高,腺瘤次之.脂联素受体表达与分化程度、淋巴结转移、TNM(tumor regional lymph node and metastasis)分期有关.脂联素受体有可能成为结直肠癌治疗的一个新靶点.AIM： To investigate the relationship between expression of adiponectin receptors R1 and R2 and clinicopathological parameters in colorectal cancer and colorectal adenomas.METHODS： Expression of adiponectin receptors R1 and R2 in surgical specimens of colorectal carcinoma （n = 51）, colorectal adenomas （n = 42）, and normal colorectal mucosa （n=35） was de- tected by irnmunohistochemistry.RESULTS： The expression of adiponectin re- ceptors R1 and R2 was significantly higher in colorectal carcinoma than in colorectal adenomas （P = 0.047, 0.035）, and in colorectal adenornas than in normal colorectal mucosa （P = 0.042, 0.046）. Expression of adiponectin receptors was signifi- cantly correlated with histological differentiation, lymph node metastasis, and TNM stages （all P 〈0.05）, but not with other clinicopathological fea- tures including sex, age, tumor size.CONCLUSION： Adiponectin receptors R1 and R2 are expressed in both colorectal carcinoma and normal colorectal mucosa. Expression of adipo- nectin receptors R1 and R2 is enhanced in colorec- tal cancer and adenomas. Adiponectin receptor expression closely correlates with tumor differ- entiation, lymph node metastasis and TNM stage in patients with colorectal cancer. Adiponectin receptors may become new targets for colorectal cancer treatment.

关 键 词：脂联素受体 结直肠癌 结直肠腺瘤 免疫 组织化学 

分 类 号：R735.3[医药卫生—肿瘤]