肿瘤相关巨噬细胞在肝癌细胞生长和转移中的作用  

Role of tumor-associated macrophages in the growth and metastasis of hepatocellular carcinoma

作　　者：郑乔丹[1] 吴文苑[1] 陈月[1] 

机构地区：[1]深圳市人民医院(暨南大学第二临床医学院)检验科,广东省深圳市518020

出　　处：《世界华人消化杂志》2012年第30期2907-2912,共6页World Chinese Journal of Digestology

基　　金：深圳市科技计划基金资助项目;No.200802102~~

摘　　要：肿瘤相关巨噬细胞(tumor-associated macrophages,TAM)与肿瘤的关系是近年来的研究热点.既往的研究表明,巨噬细胞是肿瘤发生和转移过程中的双刃剑,巨噬细胞除了抗肿瘤作用外,还可通过血管形成、细胞外基质降解和重构、增强肿瘤细胞的移动性等机制促进肿瘤的发生发展.本文将从TAM的招募、炎症、血管生成以及上皮细胞间质转化(epithelial-mesenchymaltransitions,EMT)等方面对TAM在肝细胞肝癌的发生、肝癌细胞的转移和浸润的等方面的作用进行综述,探讨临床肝细胞癌诊断治疗的新靶点.The relationship between tumorassociated macrophages （TAMs） and tumors has become a hot research topic in recent years. New evidence suggests that macrophages play a dual role in tumorigenesis and metastasis. Besides antitumor effects, macrophages in the tumor mi croenvironment can facilitate angiogenesis and extracellular matrix breakdown and remodeling and promote tumor cell mobility. In this article we summarize the role of TAMs in the growth and metastasis of hepatocellular carcinoma in terms of TAM recruitment, inflammation, angio- genesis, and epithelial-mesenchymal transition （EMT）

关 键 词：肿瘤相关巨噬细胞 肝癌 癌症进展 

分 类 号：R735.7[医药卫生—肿瘤]