miRNA单核苷酸多态性与大肠癌的研究进展  

Advances in understanding relationship between miRNA single nucleotide polymorphisms and colorectal cancer

作　　者：颜红柱[1] 许蜜蝶[1] 李彬彬[1] 余宏宇[1] 

机构地区：[1]中国人民解放军第二军医大学长征医院病理科,上海市200003

出　　处：《世界华人消化杂志》2012年第30期2920-2925,共6页World Chinese Journal of Digestology

摘　　要：大肠癌(colorectal cancer,CRC)的发生、发展是一个多因素多步骤的演进过程,基因多态性是决定肿瘤发生、发展及预后的一个重要因素.近年研究发现某些microRNA(miRNA)的单核苷酸多态性(single-nucleotide polymorph-ism,SNP)与CRC遗传易感性及预后相关,阐明相关改变机制可为CRC的早期筛查、预防及预后监测提供新线索.本文就相关研究进展作一综述.The occurrence and development of colorectal cancer （CRC） are a multifactorial, multistep evolutionary process. Gene polymorphisms are often involved in tumor development and prog nosis. Recent studies have found that certain microRNA （miRNA） single nucleotide polymorphisms were associated with genetic susceptibility to and prognosis of CRC. Understanding the relationship between miRNA single nucleotide polymorphisms and CRC can provide new clues to the detection, prevention, and prognostic evaluation of CRC.

关 键 词：MIRNA 单核苷酸多态性 大肠癌 肿瘤易 感性 预后 

分 类 号：R735.3[医药卫生—肿瘤]