脂联素及脂联素受体与肿瘤关系的研究进展  

Progress in understanding the relationship between adiponectin receptors R1&R2 and carcinomas

作　　者：畅婕[1] 宋敏[1] 

机构地区：[1]郑州大学第一附属医院肿瘤内科,河南省郑州市450052

出　　处：《世界华人消化杂志》2012年第32期3114-3117,共4页World Chinese Journal of Digestology

摘　　要：脂联素是一种由脂肪细胞特异分泌的内源性生物活性分子,与冠心病、糖尿病、高血压及肿瘤等多种疾病密切相关.具有调节糖脂代谢、改善胰岛素抵抗、抗炎、抗动脉粥样硬化及抗肿瘤的作用.近几年关于脂联素与结直肠癌、乳腺癌、子宫内膜癌、食管癌、胃癌、前列腺癌及肾细胞癌等几种恶性肿瘤的关系及其作用机制的研究取得了较大的进展.现就该领域的最新研究成果作一综述.Adiponectin is a key hormone secreted by adipocytes.It is involved in glucose and lipid metabolism and insulin sensitization,and has antiinflammatory,anti-arteriosclerosis and anti-carcinogenic effects.Many studies have found that adiponectin is related to coronary heart disease,type 2 diabetes mellitus,hypertension and cancer.Recently,adiponectin receptors R1 and R2 have been reported to be expressed in several malignancies,such as colorectal cancer,breast cancer,endometrial cancer,esophageal cancer,gastric cancer,prostate cancer and nephrocyte cancer.

关 键 词：脂联素 脂联素受体 细胞因子 脂肪细胞 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]