乳腺癌化疗相关认知障碍的前瞻性记忆损害的特征  

Chemotherapy-induced prospective memory impairment in patients with breast cancer

作　　者：程怀东[1] 陈婵娟[1] 杨震[1] 张明军[1] 陈振东[1] 汪凯[2] 

机构地区：[1]安徽医科大学第二附属医院肿瘤科,合肥230601 [2]安徽医科大学第一附属医院神经心理学实验室,230022

出　　处：《临床肿瘤学杂志》2012年第11期980-983,共4页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(81141103)

摘　　要：目的探讨乳腺癌患者出现化疗相关认知障碍(CICI)中基于事件的前瞻性记忆(EBPM)和基于时间的前瞻性记忆(TBPM)损害的特征。方法分别建立EBPM和TBPM的神经心理学测验方法,选取27例乳腺癌术后辅助化疗患者(观察组)以及年龄、教育程度相匹配的30例健康者(对照组)进行测试,记录两组数据并比较。结果观察组的EBPM得分为1.11±1.09,明显低于对照组的2.23±0.77(P<0.01);观察组和对照组的TBPM得分分别为4.33±1.24和4.83±1.09,差异无统计学意义(P>0.05)。结论乳腺癌患者出现CICI中存在前瞻性记忆损害,主要表现为EBPM损害,而TBPM损害不明显。Objective To investigate the event-based prospective memory （EBPM） and time-based prospective memory （TBPM） disorders associated with chemotherapy-induced cognitive impairment in patients with breast cancer. Methods Twenty-sev- en cases with breast cancer who underwent adjuvant chemotherapy after operation, and 30 healthy women with matched age and educa- tion level were administered with a neuropsychological battery of tests including EBPM and TBPM tasks. Results The EBPM score of breast cancer patients and healthy controls were 1.11 ± 1.09 and 2. 23 ± 0. 77, with significant differences（ P 〈 0. 001 ）. The TBPM score of breast cancer patients and healthy controls were 4. 33 ± 1.24 and 4. 83 ± 1.09 （ P 〉 0. 05 ）. Conclusion Breast cancer pa- tients who undergo adjuvant chemotherapy show deficits in EBPM, but not in TBPM.

关 键 词：乳腺癌 化学治疗 化疗相关认知障碍 前瞻性记忆 

分 类 号：R737.9[医药卫生—肿瘤]