脐血干细胞联合神经生长因子和物理康复治疗小儿脑性瘫痪  

Umbilical cord blood stem cell transplantation combined with mouse neural growth factor application and physical rehabilitation therapy for infantile cerebral palsy

作　　者：邢利和[1] 张丽欣[1] 张丽丽[1] 孙丽芳[2] 董燕慧[1] 刘影[1] 郭立杰[1] 

机构地区：[1]解放军第261医院干细胞治疗中心,北京市100094 [2]河北工业大学医院,天津市300130

出　　处：《中国组织工程研究》2012年第41期7777-7781,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:干细胞局部移植可治疗神经系统疾病。目的:观察脐血干细胞移植联合使用鼠神经生长因子及物理康复治疗小儿脑性瘫痪的临床效果。方法:将90例小儿脑性瘫痪患儿根据是否接受干细胞治疗分为3组:脐血干细胞治疗组采用脐血干细胞+鼠神经生长因子+物理康复治疗,常规治疗组采用鼠神经生长因子+物理康复治疗,对照组未行有效治疗。结果与结论:3组患儿入组前粗大运动功能测试量表各能区分值差异无显著性意义(P>0.05)。治疗后3个月,脐血干细胞治疗组及常规治疗组粗大运动功能测试量表各能区中A、B、D能区分值较治疗前提高(P<0.05),且脐血干细胞治疗组A、B能区分值均明显高于常规治疗组(P<0.05),对照组粗大运动功能测试量表各能区分值无变化(P>0.05)。表明脐血干细胞移植联合使用鼠神经生长因子、物理康复治疗治疗小儿脑瘫疗效优于鼠神经生长因子联合物理康复疗法。BACKGROUND：Umbilical cord blood stem cell transplantation is an optimal therapeutic method of nervous system diseases.OBJECTIVE：To investigate the clinical efficacy of umbilical cord blood stem cell transplantation combined with mouse neural stem cell application and physical rehabilitation therapy for infantile cerebral palsy.METHODS：90 patients with cerebral palsy were randomly and evenly divided into three groups：umbilical cord blood stem cells group（umbilical cord blood mesenchymal stem cells ＋ mouse neural growth factor ＋ physical rehabilitation therapy）,routine treatment group（mouse neural growth factor ＋ physical rehabilitation therapy） and control group（no effective treatment）.RESULTS AND CONCLUSION：Prior to treatment,there was no significant difference in gross motor function measure（GMFM） scores of each functional item among three groups（P 0.05）.Compared with prior to treatment,at 3 months after treatment,the GMFM scores of A,B,D items were significantly increased in the umbilical cord blood stem cells group and routine treatment group（P 0.05）;GMFM scores of A,B functional items were significantly higher in the umbilical cord blood stem cells group than in the routine treatment group（P 0.05）;there was no significant difference in GMFM scores of each functional item in the control group（P 0.05）.These results showed that umbilical cord blood mesenchymal stem cell transplantation combined with mouse neural stem cell application and physical rehabilitation therapy exhibits better curative effects in treatment of infantile cerebral palsy than mouse neural growth factor application combined with physical rehabilitation therapy.

关 键 词：脐血干细胞 移植 小儿脑性瘫痪 粗大运动功能 物理康复 干细胞 

分 类 号：R394.2[医药卫生—医学遗传学]