Diagnosis of Zollinger-Ellison syndrome:Increasingly difficult  

作　　者：Tetsuhide Ito Guillaume Cadiot Robert T Jensen 

机构地区：[1]Department of Medicine and Bioregulatory Science,Graduate School of Medical Sciences,Kyushu University,Fukuoka 812-8582,Japan [2]Hepato-Gastroenterology Service,Centre hospitalier universitaire de Reims,Hospital Robert Debre,F-51092 Reims,France [3]Digestive Diseases Branch,National Insitutes of Diabetes,Digestive and Kidney Diseases,National Institutes of Health,Bethesda,MD 20892,United States

出　　处：《World Journal of Gastroenterology》2012年第39期5495-5503,共9页世界胃肠病学杂志（英文版）

摘　　要：In the present paper the increasing difficulty of diag-nosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the per-spective of clinical management.In the present paper the increasing difficulty of diag- nosis of Zollinger-Ellison syndrome （ZES） due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors （omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole） and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the per- spective of clinical management.

关 键 词：Zollinger-Ellison syndrome GASTRINOMA HYPERGASTRINEMIA Secretin test Serum gastrin Gas-trin Neuroendocrine tumor 

分 类 号：R57[医药卫生—消化系统]