The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development  

作　　者：Jefri Heyman Lieven De Veylder 

机构地区：[1]Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 927, B-9052Gent, Belgium

出　　处：《Molecular Plant》2012年第6期1182-1194,共13页分子植物（英文版）

摘　　要：Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program. In light of the cell cycle, the Anaphase-Promoting Complex/Cyclosome （APC/C） is an important conserved multi-subunit ubiquitin ligase, marking targets for degradation by the 26S protea- some. However, whereas the APC/C has been studied extensively in yeast and mammals, only in the last decade has the plant APC/C started to unveil its secrets. Research results have shown the importance of the APC/C core complex and its activators during gametogenesis, growth, hormone signaling, symbiotic interactions, and endoreduplication onset. In addition, recently, the first plant APC/C inhibitors have been reported, allowing a fine-tuning of APC/C activity during the cell cycle. Together with the identification of the first APC/C targets, a picture emerges of APC/C activity being essential for many different developmental processes.Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program. In light of the cell cycle, the Anaphase-Promoting Complex/Cyclosome （APC/C） is an important conserved multi-subunit ubiquitin ligase, marking targets for degradation by the 26S protea- some. However, whereas the APC/C has been studied extensively in yeast and mammals, only in the last decade has the plant APC/C started to unveil its secrets. Research results have shown the importance of the APC/C core complex and its activators during gametogenesis, growth, hormone signaling, symbiotic interactions, and endoreduplication onset. In addition, recently, the first plant APC/C inhibitors have been reported, allowing a fine-tuning of APC/C activity during the cell cycle. Together with the identification of the first APC/C targets, a picture emerges of APC/C activity being essential for many different developmental processes.

关 键 词：cell cycle CDC20 CCS52 ENDOREDUPLICATION GAMETOGENESIS ubiquitination. 

分 类 号：Q945.4[生物学—植物学] Q511