脑白质疏松与血脂水平的关系  

Relationship between Leukoaraiosis and Blood Lipid Levels

作　　者：殷雁[1] 王齐[1] 张仲慧[1] 

机构地区：[1]大连医科大学附属第二医院神经内科,辽宁大连市116027

出　　处：《中国康复理论与实践》2012年第11期1066-1068,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨血脂水平与脑白质疏松的关系。方法 322例患者根据头颅MRI分为脑白质疏松组(LA组)181例和非脑白质疏松组(非LA组)141例。LA组根据Fazekas分级标准分为轻度组(FazekasⅠ)57例,中度组(FazekasⅡ)52例,重度组(FazekasⅢ)72例。比较各组间血脂水平。结果随着LA程度加重,总胆固醇水平逐渐升高(P<0.05),中、重度组间及低密度脂蛋白胆固醇有显著性差异(P<0.05);甘油三酯在各LA组间无显著性差异(P>0.05),但各LA组与非LA组间均有显著性差异(P<0.05);各组间高密度脂蛋白胆固醇水平无显著性差异(P>0.05)。结论总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平与LA发病有关,高密度脂蛋白胆固醇与LA发病无关;总胆固醇与低密度脂蛋白胆固醇与LA程度有关,甘油三酯与LA程度无关。Objective To investigate the relationship between blood lipids levels and leukoaraiosis （LA）. Methods 322 cases were designed into non-LA group （n=141） and LA group （n=18 l） according to MRI. LA group was further designed into mild （Fazekas I , n=57）, moderate （Fazekas Ⅱ, n=52）, and severe （Fazekas m, n=72） groups according to Fazekas classification. Their blood lipids levels were compared. Results The level of total cholesterol （TC） and low-density lipoprotein cholesterol （LDL-C） increased （P〈0.05） with the level of LA, while the level of triglycerides （TG） increased in all the LA groups （P〈0.05）, but no significant difference among them （P〉0.05）. There was no significant difference among all the groups in high-density lipoprotein cholesterol （HDL-C） （P〉0.05）. Conclusion TC, TG, and LDL-C increase in those with LA, and the TC and LDL-C increase with the severity of LA. The HDL-C do not relate with LA.

关 键 词：脑白质疏松 血脂 总胆固醇 低密度脂蛋白胆固醇 甘油三酯 

分 类 号：R742[医药卫生—神经病学与精神病学]