度洛西汀与舍曲林治疗伴有慢性疼痛抑郁症患者的疗效比较  

A comparative study of duloxetine and sertraline in the treatment of depression with chronic pain

作　　者：刘秀苹[1] 梁海翔[1] 李刚[1] 刘丽荣[1] 刘义杰[1] 

机构地区：[1]天津市安定医院,300222

出　　处：《四川精神卫生》2012年第4期222-223,共2页Sichuan Mental Health

摘　　要：目的观察度洛西汀与舍曲林治疗伴有慢性疼痛抑郁症患者的疗效。方法将60例伴有躯体疼痛症状的抑郁症患者随机分为度洛西汀组(30例)和舍曲林组(30例),观察8周。采用汉密尔顿抑郁量表17项(HAMD)、研究用疼痛量表(MOSPM)和治疗时出现的症状量表(TESS)于治疗前及治疗后第1、2、4、8周末进行评定。结果度洛西汀组与舍曲林组改善抑郁症状总体疗效及不良反应无显著性差异(P>0.05),但治疗疼痛症状度洛西汀组总体疗效显著优于舍曲林组(P<0.05)。结论度洛西汀治疗慢性疼痛的抑郁症患者安全有效,不良反应少,依从性好,度洛西汀起效时间较舍曲林快。Objective To explore the efficacy and safety of duloxetine and sertraline in the treatment of depression with chronic pain.Methods 60 outpatients diagnosed as depression with chronic pain were divided into two groups randomly.The duloxetine group(n=30) and sertraline group(n=30) for 8 weeks.The efficacy and side effects were evaluated with HAMD,MOSPM and TESS before the therapy and the 1,2,4 and 8 week.Results There were no difference in the total efficacy and side effects between the two groups(P>0.05),but duloxetine behaves better in the treatment of chronic pain(P<0.05)groups.Conclusion Duloxetine in the treatment of depression with chronic pain would be safe and effective,have good compliance,and take into effect faster than sertraline.

关 键 词：度洛西汀 舍曲林 慢性疼痛 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]