Wnt信号通路抑制因子Dickkopf-1在宫颈癌中的研究进展  

Research Progress in the Role of Wnt Signaling Pathway Antagonist Dickkopf-1 in Cervical Cancer

作　　者：崔素芬[1] 包广宇[1] 张玲玲[1] 

机构地区：[1]扬州市第一人民医院妇产科,江苏扬州225012

出　　处：《医学综述》2012年第22期3770-3772,共3页Medical Recapitulate

基　　金：江苏省自然科学基金(BK2009195)

摘　　要：Wnt信号通路的异常激活在肿瘤的发病和进展过程中发挥着重要作用。Dickkopf-1(DKK-1)作为Dickkopf家族中的一员,是经典Wnt信号通路的胞外拮抗剂。目前研究发现,经典Wnt信号通路和DKK-1参与宫颈癌的发生、发展,抗DKK-1中和抗体BHQ880治疗多发性骨髓瘤已经进入临床Ⅰ/Ⅱ期试验。现就DKK-1在宫颈癌中的研究进展予以综述,为宫颈癌的诊断、治疗及预后判断提供一个新的、重要的生物学标志物。Aberrant activated Wnt signaling pathway plays a vital role in tumorigenesis and progression.Dickkopf-1（DKK-1）,a member of Dickkopf family,is a secreted glycoprotein that acts as an extracellular antagonist of canonical Wnt signaling pathway.Recently,a number of studies have found that aberrant canonical Wnt pathway and DKK-1 implicate in the occurrence and development of cervical cancer.Anti-DKK-1 neutralizing antibody BHQ880,is currently in Phase Ⅰ/Ⅱ clinical trials for treating multiple myeloma.Here is to make a review on the research progress of the role of DKK-1 in cervical cancer,providing a new valuable biomarker in cancer detection,treatment and prognosis.

关 键 词：DICKKOPF-1 WNT信号通路 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]