VEGF-C及癌周淋巴管密度与头颈鳞癌颈部淋巴结转移的关系  

Correlation of VEGF-C Expression and Peritumoral Lymphatic Vessel Density with Nodal Metastasis in HNSCC

作　　者：邓莅霏[1] 齐淑轶[1] 刘学明[1] 石冬梅[1] 高文[1] 

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2012年第6期565-567,585,共4页The Practical Journal of Cancer

基　　金：江西省卫生厅科技计划项目(20061143)

摘　　要：目的探讨血管内皮细胞生长因子-C(VEGF-C)表达及癌周淋巴管密度(P-LVD)与头颈鳞癌(HNSCC)颈部淋巴结转移的关系。方法采用免疫组化法,检测104例HNSCC组织中VEGF-C及癌周LYVE-1的表达,幷计算P-LVD,分析P-LVD及VEGF-C表达与其临床病理因素的关系。结果 104例HNSCC组织中,VEGF-C阳性表达率显著高于正常头颈部黏膜组织(74.04%vs 0,P<0.05)。淋巴结转移组VEGF-C阳性表达率高于无淋巴结转移组(P<0.05)。对LYVE-1标记的淋巴管密度(LVD)分析显示,癌周组织P-LVD高于癌内及正常组织(P<0.05),而VEGF-C阳性表达者及颈部淋巴结转移者P-LVD分别显著高于VEGF-C阴性表达者和无颈部淋巴结转移者(P<0.05)。结论 HNSCC中VEGF-C表达及P-LVD与肿瘤淋巴结转移密切相关,对判断肿瘤侵袭、转移具有一定参考价值。Objective To investigate the relationship between VEGF-C expression,peritumoral lymphatic vessel density（P-LVD） and lymph node metastasis in head neck squmaous cell carcinoma（HNSCC）.Methods P-LVD and expression of VEGF-C was detected,respectively,by immunohistochemical staining with the antibody to VEGF-C and LYVE-1 in 104 cases of HNSCC.The correlation of clinico-pathological feature with VEGF-C expression and PLVD wes evaluated.Results The positive rates of VEGF-C in HNSCC tissues and normal oral mucousa membrane were 74.04% and 0 respectively（P0.05）.The expressions of VEGF-C was significantly higher in lymph node metastasis positive patients than those of metastasis negative patients（P0.05）.Analysis of LVD labelled by LYVE-1 showed that P-LVD was significantly higher than intratumoral LVD（I-LVD） and LVD in normal tussues（P0.05）.Patients of VEGF-C positive group and lymph node metastasis positive group had,respectively,higher P-LVD than those of VEGF-C negative group and lymph node metastasis negative group（P0.05）.Conclusion VEGF-C expression and P-LVD were closely correlated with regional lymph node metastasis in HNSCC and may be valuable in the evaluation of potential for invasivness and metastasis.

关 键 词：头颈鳞癌 血管内皮生长因子C 淋巴管内皮细胞透明质酸受体1 淋巴管密度 免疫组化 

分 类 号：R739.91[医药卫生—肿瘤]