三阴型乳腺癌159例临床病理特征分析  

Clinicopathologic Features of 159 Triple Negative Breast Cancer

作　　者：李春艳[1] 张晟[1] 刘艳[1] 张瑾[1] 

机构地区：[1]天津医科大学附属肿瘤医院,乳腺癌防治教育部重点实验室,天津市肿瘤防治重点实验室,300060

出　　处：《实用癌症杂志》2012年第6期624-626,共3页The Practical Journal of Cancer

摘　　要：目的探讨三阴型乳腺癌的临床病理特征。方法选取2003年3月～2003年11月手术切除并经病理检查证实的女性原发性乳腺癌747例。根据ER、PR、Her-2免疫组织化学表达情况,将747例乳腺癌分为2组,即ER、PR、Her-2蛋白均为阴性的三阴型乳腺癌和非三阴型乳腺癌。比较2组乳腺癌的临床病理特征。结果 747例乳腺癌病例中,159例为三阴型乳腺癌[ER(-)、PR(-)、Her-2(-)],占21.3%。2组乳腺癌在组织学分级上差异有统计学意义(P<0.05),三阴型组的组织学Ⅲ级占比高于非三阴型组。三阴型乳腺癌复发转移率高于非三阴型乳腺癌,但无统计学差异(P=0.236)。结论三阴型乳腺癌较非三阴型乳腺癌病理恶性程度高,预后更差。Objective To analyze the clinicopathologic features of 747 cases of triple negative breast cancer.Methods 747 cases of operable breast cancer between March 2003 and Novenmber 2003 were analyzed.Immunohistochemistry was used to determine Her-2,ER and PR status.The patients were divided into the triple negative breast cancer group（ER negative,PR negative and Her-2 negative） and the non-triple negative breast cancer group.The clinicopathologic features of the two groups were compared.Results Of the 747 patients,21.3%（159/747）had triple negative breast cancer and 78.7%（588/747）had non-triple negative breast cancer.The percentage of cases with medullary type or grade Ⅲ was higher in the triple negative groups than in the non-triple negative group.There was significant difference in histological grade between the two groups（P0.05）.Recurrence and metastasis of triple negative breast cancer group was higher than that of non-triple negative breast cancer group,but there was no significant difference（P=0.236）.Conclusion Compared with non-triple negative breast cancer,triple negative breast cancer has a higher histological grade and a worse prognosis.

关 键 词：乳腺癌 三阴 预后 ER蛋白 PR蛋白 HER-2蛋白 

分 类 号：R737.9[医药卫生—肿瘤]