丁苯酞对急性脑梗死患者临床疗效及血液流变学的影响  

Effects of Butylphthalide on clinical efficacy and hemorheology in patients with acute cerebral infarction

作　　者：吴娟[1] 陈永[1] 

机构地区：[1]重庆市第三人民医院老年科,400014

出　　处：《重庆医学》2012年第33期3488-3489,共2页Chongqing medicine

基　　金：重庆市医学科研计划项目(2012-2-222)

摘　　要：目的观察丁苯酞治疗急性脑梗死的临床疗效及其对血液流变学的影响。方法将急性脑梗死患者112例,随机分成治疗组和对照组。治疗组采用丁苯酞软胶囊0.2g,口服,3次/天;对照组给予维生素E胶囊0.1g,口服,3次/天,14d为一疗程。两组均给予抗血小板药、改善血循环药物以及神经营养药等治疗。观察两组患者治疗前、后血液流变学的变化以及临床疗效,并监测用药后的不良反应。结果治疗组血液流变学各项指标较对照组明显改善。治疗组总有效率为94.64%,对照组为85.71%,两组比较差异有统计学意义(P<0.05)。未发现明显的不良反应。结论丁苯酞能改善急性脑梗死患者的血液流变学,临床疗效显著,无明显的不良反应。Objective To study the effects of Butylphthalide on hemorheology and clinical efficacy in patients with acute cerebral infarction.Methods 112 patients with acute cerebral infarction were randomly divided into two groups.56 patients of therapeutic group were treated with Butylphthalide soft capsule 0.2 g,orally,three times per day for 14 days.Another 56 patients of control groups were treated with Vitamin E capsule 0.1 g orally,three times per day for 14 days.The two groups received the same conventional therapy（bayaspirin enteric-coated tablets,monosialoganglioside,vitamins,etc）.The therapeutic efficacy and side effects were observed.The changes of hemorheology index were observed before and after treatment.Results Hemorheology index was significantly improved in therapeutic group.Total effective rate was 94.64% in therapeutic group and 85.71% in control group,there was significant difference between the two groups（P0.05）.There were no adverse reactions in two groups.Conclusion Butylphthalide can improve the hemorheology of patients with acute cerebral infarction.Butylphthalide is an effective drug for treating the acute cerebral infarction,and has no adverse reactions.

关 键 词：丁苯酞 脑梗死 血液流变学 治疗结果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]