Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia  

作　　者：Hyun Chul Lim Sang In Lee Jiande DZ Chen Hyojin Park 

机构地区：[1]Department of Internal Medicine,Yonsei University College of Medicine,Seoul 120-752,South Korea [2]Division of Gastroenterology,Department of Internal Medicine,University of Texas Medical Branch,Galveston,TX 77555,United States

出　　处：《World Journal of Gastroenterology》2012年第41期5948-5956,共9页世界胃肠病学杂志（英文版）

摘　　要：AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010.We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment.We also measured cutaneous pre-prandial and postprandial EGG recordings including percentage of gastric waves(normogastria,bradygastria,tachygastria),dominant frequency(DF),dominant power(DP),dominant frequency instability coefficient(DFIC),dominant power instability coefficient(DPIC),and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment.RESULTS:Fifty-two patients(70%) achieved symptomatic improvement after prokinetic drug treatment.Patients who had normal gastric slow waves showed symptom improvement group after treatment.Postprandial DF showed a downward trend in the symptom improvement group,especially in the itopride group.Post-prandial DP was increased regardless of symptom improvement,especially in the itopride group and mosapride group.Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment.The EGG power ratio was increased after treatment in the symptom improvement group(0.50 ± 0.70 vs 0.93 ± 1.77,P = 0.002),especially in the itopride and levosulpiride groups.CONCLUSION:Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity,and EGG could be a useful tool in evaluating the effects of various prokinetics.AIM： To evaluate the effect of prokinetic drugs on elec- trogastrography （EGG） parameters according to symp- tomatic changes in patients with functional dyspepsia （FD）. METHODS： Seventy-four patients with FD were pro- spectively enrolled in this study between December 2006 and December 2010. We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment. We also measured cutaneous pre-prandial and post- prandial EGG recordings including percentage of gas- tric waves （normogastria, bradygastria, tachygastria）, dominant frequency （DF）, dominant power （DP）, domi- nant frequency instability coefficient （DFIC）, dominant power instability coefficient （DPIC）, and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment. RESULTS： Fifty-two patients （70%） achieved symp- tomatic improvement after prokinetic drug treatment. Patients who had normal gastric slow waves showed symptom improvement group after treatment. Post- prandial DF showed a downward trend in the symptom improvement group, especially in the itopride group. Post-prandial DP was increased regardless of symp- tom improvement, especially in the itopride group and mosapride group. Post-prandial DFIC and DPIC in the symptom improvement group were significantly in- creased after the treatment. The EGG power ratio was increased after treatment in the symptom improvement group （0.50 ＋ 0.70 vs 0.93 ＋ 1.77, P = 0.002）, espe- cially in the itopride and levosulpiride groups. CONCLUSION： Prokinetics could improve the symp- toms of FD by regulating gastric myoelectrical activity, and EGG could be a useful tool in evaluating the effects of various prokinetics.

关 键 词：ELECTROGASTROGRAPHY Functional dyspepsia ITOPRIDE MOSAPRIDE Levosulpiride 

分 类 号：R57[医药卫生—消化系统]