我国肠道病毒71型灭活疫苗研发现状  

Research and development status of inactivated whole-virus vaccine of enterovirus 71 in China

作　　者：梁争论[1] 

机构地区：[1]中国食品药品检定研究院卫生部生物技术质量控制重点实验室,北京100050

出　　处：《中国病毒病杂志》2012年第6期401-403,共3页Chinese Journal of Viral Diseases

基　　金：国家科技支撑计划(2008BAI69B01);国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2009ZX10004-804)

摘　　要：肠道病毒71型（enterovirus 71,EV71）属小RNA病毒科肠道病毒属,主要引起手足口病（hand-foot-and-mouth disease,HFMD）和中枢神经系统等相关疾病。自美国加里福尼亚于1969年分离出首株EV71以来,近年来在亚太地区EV71呈高流行态势。Enterovirus 71（EV71） is the major pathogen for hand-foot-mouth disease（HFMD） and can cause severe complications of the neural system.In recent years,outbreaks of EV71 have been increasing in China which lead to severe public health problems.Development of a safe and effective vaccine for the prevention and control of HFMD is an urgent issue which needs to be resolved.Inactivated whole-virus vaccines of EV71 are under development in several domestic pharmaceutical manufactures and 3 products have entered the phase III clinical trial.This review summarizes the progress and quality control of the inactivated EV71 whole-virus vaccine in China.

关 键 词：手足口病 肠道病毒71型 灭活全病毒疫苗 

分 类 号：R392.1[医药卫生—免疫学]