热休克蛋白70-hom基因多态性与老年脑梗死易感性的研究  

Correlation between heat shock protein 70-hom gene polymorphisms and susceptibility to cerebral infarction in the elderly

作　　者：何燕[1] 魏云鸿[1] 杨文慧[1] 金醒昉[1] 

机构地区：[1]昆明医科大学附属延安医院干疗科,650051

出　　处：《中华老年心脑血管病杂志》2012年第12期1271-1274,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：云南省科技计划项目(2007C0041R);昆明市卫生局立项备选基金(2007-4-1)

摘　　要：目的探讨热休克蛋白70(Hsp70)-hom基因多态性与老年脑梗死和高血压发生的关系。方法选择住院和门诊的老年患者220例,按诊断分为脑梗死组105例和高血压组115例,脑梗死组又分为单纯组38例和合并组67例,同期选取健康体检者100例为健康组。采用PCR-RFLP方法检测Hsp70-hom+2437位点基因多态性。结果与健康组比较,脑梗死组Hsp70 hom TT基因型及T等位基因明显升高,分别达到70.48%和82.38%(OR=3.311,95%CI:2.078～4.359,P=0.000;OR=2.121,95%CI:1.271～3.325,P=0.003)。与健康组比较,合并组、单纯组C与T等位基因频率有显著差异(OR=1.193,95%CI:1.128～3.246,P<0.05;OR=2.31 2,95%CI1.128～4.721,P<0.05)。结论 Hsp70 hom基因多态性与脑梗死易感性有关,Hsp70 hom+2437位点基因型的检测价值,值得进一步探讨。Objective To study the correlation of heat shock protein 70-hom（Hsp70-hom） gene polymorphisms with susceptibility to cerebral infarction and hypertension in the elderly. Methods Two hundred and twenty elderly patients were divided into cerebral infarction group（n= 105） and hypertensin group（n=115）. Patients in cerebral infarction group were further divided into simple cerebral infarction group（n = 38）and cerebral infarction plus hypertension group（n= 67）. One hundred healthy subjects served as a control group. Hsp70-hom ＋2437 gene polymorphisms were detected by PCR-RFLP. Results The proportion of HspT0-hom TT genotypes and T alleles was significantly higher in cerebral infarction group than in control group （70.48%, 82. 38%, OR= 3.311,95%CI：2.078-4.359,P=0.000;OR=2. 121,95%CI：l. 271-3. 325,P：0. 003）. The proportion of C and T alleles was significantly different among cerebral infarction plus hypertension group, simple cerebral infarction group, and control group （OR = 1. 193,95 % CI. 1. 128- 3. 246,P〈0.05;OR= 2. 312,95% CI： 1. 128-4. 721, P〈0. 05）. Conclusion polymorphisms are correlated with the susceptibility to cerebral infarction. The Hsp70-homq-2437 genotypes should be further studied. Hsp70-hom gene value of detecting

关 键 词：脑梗死 热休克蛋白质类70 高血压 基因型 基因频率 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]