二丁酰环磷腺苷钙联合依达拉奉治疗急性脑出血的疗效观察  

Combined dbc AMP-Ca and edaravone in treatment of acute cerebral hemorrhage

作　　者：赵峻波[1] 薛俊峰[1] 姬馨彤[1] 冯兵[1] 

机构地区：[1]焦作市人民医院神经外科二区,454000

出　　处：《中华老年心脑血管病杂志》2012年第12期1296-1297,共2页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的观察二丁酰环磷腺苷钙联合依达拉奉治疗急性脑出血的临床疗效。方法选择急性脑出血患者95例,随机分为2组,治疗组(50例)采用二丁酰环磷腺苷钙联合依达拉奉治疗,对照组(45例)采用依达拉奉治疗,2组疗程均为14 d,比较2组治疗总有效率及神经功能缺损评分。结果治疗组总有效率明显高于对照组,差异有统计学意义(86.0%vs 71.1%,P<0.05);治疗组治疗后神经功能缺损评分明显低于对照组[(11.09±5.31)分vs(16.73±5.57)分,P<0.05]。结论二丁酰环磷腺苷钙联合依达拉奉治疗急性脑出血疗效显著,安全可靠,值得临床推广应用。Objective To observe the clinical curative effect of combined dbc AMP-Ca and edaravone on acute cerebral hemorrhage. Methods Ninety-five patients with acute cerebral hemorrhage were randomly divided into combined dbc AMP-Ca and edaravone treatment group（n： 50） and edaravone treatment group serving as a control group（n： 45） with 14 days as a course of treatment. The total effective rate and nerve function deficit score were compared between the two groups. Results The total effective rate was significantly higher whereas the nerve function score was significantly lower in combined dbc AMP-Ca and edaravone treatment group than in control group（86.0% vs 71.1%,11. 09±5. 31 vs 16.73± 5.57,P〈0.05）.Conclusion Combined dbc AMP-Ca and edaravone is a safe and reliable treatment modality for acute cerebral hemorrhage and is thus worthy of application in clinical practice.

关 键 词：脑出血 自由基 脂质过氧化作用 依达拉奉 二丁酰环磷腺苷 

分 类 号：R743.34[医药卫生—神经病学与精神病学]