EGCG衍生物在高温和低温强光照射下的稳定性研究  

STUDY ON THE THERMAL STABILITY AND LIGHT PHOTOSTABILITY OF EGCG DERIVATIVES

作　　者：欧冰凝[1] 周焕第[2] 梁钢[1] 孙悦文[1] 

机构地区：[1]广西医科大学药学院,南宁530021 [2]广西中医药大学药学院,南宁530001

出　　处：《广西医科大学学报》2012年第5期672-674,共3页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.30760310);广西自然科学基金资助项目(No.2010GXNSFD013043)

摘　　要：目的:了解表没食子儿茶素没食子酸酯(EGCG)衍生物的稳定性。方法:用高效液相色谱(HPLC)测定EGCG及其衍生物在60℃和低温强光照射下的稳定性。结果:在60℃和低温强光照射10d后,全乙酰化EGCG(AcEGCG)和丙基化EGCG(2c)的含量均基本不变,而EGCG的含量分别约为5%和10%。结论:在高温和低温强光照射下,固体AcEGCG和2c均比EGCG稳定。Objective： To study the stability of （-）-epigallocatechin gallate derivatives. Methods： The stability of AcEGCG, 2c and EGCG solid was determined by HPLC. The open weighing bottle with powder of AcEGCG, 2c or EGCG was put at 60℃ and in light box （6-7℃, 4500 LX）, respectively, 5 mg AcEGCG,2c or EGCG was taken out of weighing bottle at 0, 5, 10 d, and the content of AcEGCG or EGCG was analyzed by HPLC. Results： From 0 to 10 d, the content of AcEGCG or 2c did not change both at 60℃ and in light box, but the content of EGCG decreased by 5% at 60℃ and 10% in light box, respectively.Conclusion. AcEGCG and 2c solid are much more stable than EGCG solid at 60℃ and in light box.

关 键 词：EGCG 衍生物 稳定性 HPLC 

分 类 号：R-332[医药卫生]