颅内外大动脉闭塞性脑梗死患者危险因素和hs-CRP的变化  

Study on changes of risk factors and serum level of high sensitivity C-reactive protein(hs-CRP) in patients with intracranial and extracranial arteries occlusive diseases

作　　者：谢聃[1] 邓丽[1] 刘晓冬[1] 张拥波[1] 李继梅[1] 

机构地区：[1]首都医科大学附属北京友谊医院神经内科,北京100050

出　　处：《临床和实验医学杂志》2012年第23期1845-1846,1848,共3页Journal of Clinical and Experimental Medicine

基　　金：北京市卫生系统高层次卫生技术人才培养计划项目资助(2009-3-07)

摘　　要：目的分析颅内外大动脉闭塞患者的危险因素及血液中超敏C反应蛋白(hs-CRP)的变化。方法回顾性病例-对照研究276例患者,其中颈内动脉闭塞89例,大脑中动脉闭塞74例,颈内动脉合并大脑中动脉闭塞29例,除外颅内外大动脉闭塞的脑缺血患者84例。记录其危险因素及入院后3天内hs-CRP水平,并进行统计学分析。结果与非闭塞的脑缺血患者比较,颅内外动脉闭塞患者多合并冠心病和脑卒中病史(P<0.01),并且闭塞组23.6%～31.0%患者含有3个以上的多重危险因素,而对照组仅有3.6%,两者比较均有显著性差异。hs-CRP在各闭塞组中的浓度均明显高于对照组(P<0.01)。结论颅内外动脉闭塞患者多含有多个危险因素,并且多合并冠心病和脑卒中病史。hs-CRP作为重要的炎性因子,可能参与了颅内外大动脉闭塞的病理生理过程,在其临床生化中具有重要意义。Objective To study the changes in risk factors and serum level of high sensitivity C - reactive protein （hs - CRP） in patients with intraeranial and extracranial arteries occlusive diseases. Methods This study was a retrospective case - control study. The total numbers of patients were 276, including 89 patients with ICAO, 74 patients with MCAO, 29 patients with ICAO and MCAO, and 84 ischemie stroke patients without large artery occlusion （control group）. The risk factors and serum level of hs - CRP within 3 days after admission were examined and re- corded, combined with TCD, CTA and MRA and other imaging and clinical data, its characteristics were analyzed and summarized, and statistical analysis had been made. Results Compared with control group, patients with intracranial and extracranial arteries occlusive diseases had higher percentage of history of stroke and coronary heart diseases （ P 〈 0.01 ） , and 23.6% ~ 31.0% of patients had more than three risk factors, and in- cidence rate of control group was only 3.6%. The level of hs - CRP was also higher （ P 〈0.01 ） in patients with intraeranial and extracranial ar- teries occlusive diseases. Conclusion Stroke patients with intraeranial and extraeranial arteries occlusive diseases have more risk factors and high- er percentage of history of stroke and coronary heart diseases. The hs -CRP, as an important inflammatory factor, may be involved in the patho- physiological process of intracranial or extracranial artery occlusion, and they may play an important role in changes of clinical biochemistry.

关 键 词：缺血性脑卒中 颈内动脉闭塞 大脑中动脉闭塞 危险因素 超敏C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]