f/tPSA、PSAD在PSA灰区对前列腺增生症和前列腺癌诊断效用的研究  

Value of f/tPSAD and PSAD in PSA gray zone in the diagnosis of benign prostatic hyperplasia and prostatic cancer.

作　　者：孙鹏[1] 包卫东[1] 杨莉莉[2] 沈俭[1] 顾燕青[1] 沈伟[1] 沈杰[1] 俞奇伟[1] 陈建华[1,3] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院泌尿外科,上海202150 [2]蚌埠医学院临床1系,2007级4班安徽蚌埠233030 [3]上海交通大学医学院附属新华医院泌尿外科,上海200092

出　　处：《海南医学》2012年第24期4-6,共3页Hainan Medical Journal

基　　金：上海交通大学医学院附属新华医院崇明分院院级课题(编号:Y201012)

摘　　要：目的探讨在PSA灰区(tPSA4-10ng/ml)前列腺特异性抗原(PSA)、游离前列腺特异性抗原/总前列腺特异性抗原(f/tPSA)、前列腺特异性抗原密度(PSAD)对前列腺增生症(BPH)、前列腺癌(PCa)的诊断效用。方法 162例患者经临床确诊后分为BPH组104例和PCa组58例,分别检测其血清PSA、f/tPSA、直肠超声检测前列腺体积并测算PSAD数值。结果 PCa组血清tPSA与BPH组之间差异无统计学意义(P>0.05)。PCa组血清f/tPSA较BPH组明显降低(P<0.01),PCa组PSAD值较BPH组明显升高(P<0.01)。随f/tPSA、PSAD升高,PCa诊断的敏感度也升高但特异度下降。PSAD对PCa诊断特异度明显高于f/tPSA比值。结论 f/tPSA比值和PSAD对诊断BPH、PCa具有重要意义。Objective To investigate the diagnostic significance of f/tPSA, PSAD in PSA gray zone （tPSA 4- 10 ng/ml） for benign prostatic hyperplasia （BPH）; and prostatic cancer （PCa）. Methods One hundred and sixty-two patients with BPH or PCa were divided into BPH group （n=104） and PCa group （n=58）. The serum PSA, f/tPSA were de- tected. Prostate volume and PSAD were calculated. Results The serum tPSA showed no statistically significant differ- ence between the two groups （P〉0.05）. The serum f/tPSA in PCa group was significantly lower than that of BPH group （P〈 0.01）. PSAD in PCa group is prominently higher than that BPH group （P〈0.01）.With f/tPSA, PSAD increased, the diagnos- tic sensitivity of PCa is increased, while specificity decreased. The diagnostic specificity of PSAD for PCa is significantly higher than that of f/tPSA. Conclusion PSAD is more suitable for differentiating BPH and PCa than f/tPSA.

关 键 词：前列腺特异性抗原(PSA) 前列腺特异性抗原密度(PSAD) 前列腺增生症(BPH) 前列腺癌(PCa) 

分 类 号：R737.25[医药卫生—肿瘤]