环糊精与油制备自组装小珠载药系统的研究进展  

Research progress of self-assembled beads drug delivery system prepared from cyclodextrins and oils

作　　者：刘川[1] 易涛[1,2] 

机构地区：[1]西南大学药学院,重庆400715 [2]澳门科技大学,中药质量研究国家重点实验室,澳门药物及健康应用研究所,中国澳门000853

出　　处：《药学学报》2012年第12期1582-1586,共5页Acta Pharmaceutica Sinica

基　　金：中央高校基本科研业务费专项资金(XDJK2009C076);重庆高校优秀成果转化(KJ08B06);西南大学博士基金项目(SWUB2008032)

摘　　要：采用环糊精和油制备新型自组装载药系统——小珠受到越来越多的关注。小珠是一种球状颗粒,具有脂质囊腔结构,在制备过程中不需使用任何表面活性剂或有机溶剂。小珠囊腔内的脂质部分可溶解水难溶性药物和脂溶性药物,载药量大、能提高口服生物利用度,是很有发展潜力的口服新剂型。本文综述了小珠的制备原理、处方工艺和体内外性质等方面的研究进展,为其进一步应用提供基础。Recently, increasing attention has been paid to beads, an innovative self-assembled drug delivery system prepared from cyclodextrins and oils. Beads are new core-shell minispheres containing poorly water- soluble drugs or lipophilic drugs dissolved in the lipid core without the use of organic solvents and surfactants. Therefore, beads with high drug loading and improved oral bioavailability have great potential for oral delivery of poorly water-soluble drugs and lipophilic drugs. The preparation mechanisms, formulations and methods, the in vitro and in vivo properties of beads were reviewed in order to provide the theoretical basis for further application of beads.

关 键 词：环糊精 油 自组装 小珠 难溶性药物 脂溶性药物 

分 类 号：R943[医药卫生—药剂学]