细胞因子在糖尿病视网膜病变中的研究进展  

Study progress of cytokine in diabetic retinopathy

作　　者：王小琴[1,2] 谢青[1,2] 

机构地区：[1]中南大学湘雅医学院附属海口医院 [2]海口市人民医院眼科,中国海南省海口市570000

出　　处：《国际眼科杂志》2012年第12期2312-2314,共3页International Eye Science

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病最严重和最常见的微血管并发症之一,也是一种世界范围内主要的致盲性眼病。其发病机制相当复杂,目前尚未完全明确。经典理论包括多元醇代谢异常、糖基化终产物的形成增加、蛋白激酶C的活化、氧化应激等。近年来,随着分子生物学的发展,分子基础研究已成为目前DR发病机制研究的焦点和热点。目前已知与DR有关的细胞因子有VEGF,IGF-1,bFGF,TNF等。多种细胞因子通过信号转导系统形成复杂的网络系统,引起新生血管生成,破坏血-视网膜屏障等多种改变,从而导致DR的发生发展。本文就细胞因子表达异常与DR的关系进行综述。Diabetic retinopathy（DR） is one of the most serious and common microvascular complications of diabetes, it is a major cause of blindness all over the world. The pathogenesis of DR is very complex and are still being elucidated at present. The classic theory includes abnormal metabolism of polyol, increased advanced glycation end products, activation of protein kinase C, oxidative stress, etc. Recently, with the rapid development of molecular biology, the research of molecular basis has become the focus and hot topic. Cytokines have been shown to involve in the progress of DR such as VEGF, IGF-1, bFGF, etc. A variety of cytokines can induce intraocular angiogenesis through complex signal transduction system, break down blood retinal barrier, and finally result in the development of DR. This article reviews the relationship between cytokine and the progress of DR.

关 键 词：糖尿病视网膜病变 发病机制 细胞因子 研究进展 

分 类 号：R774.1[医药卫生—眼科]