低剂量PDT治疗中心性浆液性脉络膜视网膜病变  

Efficacy of photodynamic therapy with 1/2 dose verteporfin for treating central serous chorioretinopathy

作　　者：庄晓彤[1] 肖伟[2] 

机构地区：[1]中国辽宁省沈阳市第四人民医院眼科,110031 [2]中国医科大学附属盛京医院眼科,中国辽宁省沈阳市110001

出　　处：《国际眼科杂志》2012年第12期2368-2370,共3页International Eye Science

摘　　要：目的:观察低剂量光动力学疗法(photodynamic therapy,PDT)治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)的短期疗效。方法:选取急性CSC患者36例36眼,进行单次1/2量维替泊芬(3mg/m2)进行PDT治疗,分别于术前和术后1,4,12,24wk进行最佳矫正视力和OCT的检查,术前、术后4,24wk进行FFA和ICG检查。结果:术后1wk,36眼中有27眼(75%)OCT显示视网膜下积液完全吸收,其余9眼(25%)视网膜下液部分吸收;术后4wk,36眼视网膜下积液全部吸收,FFA+ICG示36眼荧光渗漏完全消失,脉络膜血管高渗透性消失;术后12～24wk,36眼无复发。治疗后4wk,最佳矫正视力从术前平均0.52提高至0.80。随访期间36眼未见任何不良反应。结论:低剂量PDT治疗CSC短期内安全有效,能缩短病程,显著提高视力。AIM：To evaluate the efficacy of photodynamic therapy （PDT） after 1/2 dose verteporfin injection in treating central serous chorioretinopathy （CSC）.METHODS：Thirty-six eyes of 36 patients diagnosed with CSC received one single session of PDT using 1/2 dose （3mg/m2） verteporfin. Best-corrected visual acuity （BCVA） and OCT were measured before, 1 week, 4, 12 and 24 weeks after PDT treatment with 1/2 dose. OCT, FFA and ICG examination were performed before,4 and 24 weeks after PDT treatment with 1/2 dose.RESULTS：Twenty-seven of 36 eyes （75%） had complete resolution of subretinal fluid （SRF） 1 week after 1/2 dose PDT treatment. SRF was partly absorbed in 9 of 36 eyes （25%）. After 4 weeks, SRF in 36 eyes was completely absorbed, fluorescein leakage of 36 eyes disappeared in FFA and the tortuous choroidal vessels appeared normal in ICG; Twelve to twenty-four weeks after PDT treatment, there was no recurrence of CSC in 36 eyes. The mean BCVA was improved from 0.52 to 0.80 four weeks after PDT treatment.CONCLUSION：PDT with 1/2 dose verteporfin injection is effective and safe in treating CSC in short time follow-up. It can shorten the coursing of CSC and protect the macular visual function.

关 键 词：中心性浆液性视网膜脉络膜病变 光动力疗法 

分 类 号：R774.1[医药卫生—眼科]