聚焦超声治疗低级别宫颈上皮内瘤样病变  

Focused ultrasound in treatment of low grade cervical intraepithelial neoplasia

作　　者：林川[1] 杨君[2] 李成志[1] 刘玉明[2] 周德平[2] 

机构地区：[1]重庆医科大学生物医学工程学院省部共建超声医学工程国家重点实验室超声医学工程重庆市市级重点实验室,重庆400016 [2]重庆市妇幼保健院宫颈门诊,重庆400016

出　　处：《中国介入影像与治疗学》2012年第12期873-876,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家重点基础研究发展计划(973计划)项目(2011CB707902);聚焦超声用于治疗宫颈高危型HPV感染的临床研究(2010-2-318)

摘　　要：目的探讨聚焦超声技术在治疗宫颈上皮内瘤样病变(CIN)Ⅰ～Ⅱ级中的应用价值。方法收集78例经病理学证实的CINⅠ级及Ⅱ级患者,行聚焦超声治疗,其中CINⅠ级患者随机分为A1、A2及A3组,CINⅡ级随机分为B1、B2及B3组,分别给予不同的辐照剂量,6个月后行液基薄层细胞学检查(TCT),必要时行阴道镜或病理组织学检查。结果 A3组患者治愈率为88.24%(15/17),与A1、A2组差异均有统计学意义(P均<0.0167);B3组患者治愈率为81.82%(9/11),与B1组治愈率的差异有统计学意义(P<0.0167),而与B2组差异无统计学意义(P>0.0167)。结论采用适当治疗剂量的聚焦超声能够安全、有效地治疗低级别CIN。Objective To observe the effect of focused ultrasound in the treatment of cervical intraepithelial neoplasia （CIN） Ⅰ-Ⅱ. Methods Totally 78 patients with CIN Ⅰ-Ⅱ confirmed pathologically underwent focused ultrasound treatment. Patients with CIN I were randomly divided into group A1, A2 and A3, and those with CIN Ⅱ were divided in- to group B1, B2 and B3. Different irradiation doses were given, respectively. All patients underwent thinprep cytologic test and vaginal mirror or histologic examination if necessary after 6 months. Results The cure rate in group A3 was 88.24% （15/17）, significantly different with that of group A1 and A2 （both P〈0. 0167）. In group B3, the cure rate was 81.82% （9/11）, statistically different with that in group B1 （P（0. 0167）, but not with that in group B2 （P〉0. 0167）. Conclusion Focused ultrasound with appropriate dosage can be used to treat CIN Ⅰ -Ⅱ effectively and safely.

关 键 词：聚焦超声 宫颈上皮内瘤样病变 疗效 辐射剂量 

分 类 号：R737.33[医药卫生—肿瘤]