益生菌对大肠癌辅助化疗期免疫功能的影响  

Effects of probiotics on immune function in postoperative colorectal cancer patients receiving adjuvant chemotherapy

作　　者：孙校男[1,2] 郭勇[3] 朱明利[2] 

机构地区：[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]杭州市第六人民医院,浙江杭州310014 [3]浙江中医药大学附属第一医院,浙江杭州310006

出　　处：《实用肿瘤杂志》2012年第6期610-612,共3页Journal of Practical Oncology

摘　　要：目的观察益生菌对大肠癌辅助化疗期脾虚证患者的肠道菌群及免疫功能的影响。方法将60例大肠癌辅助化疗期脾虚证患者随机分为益生菌组、中药组和对照组。3组在常规化疗基础上分别予中药加益生菌、中药、未行中药及益生菌治疗,治疗4周。观察治疗前后T细胞亚群、大便SIgA及肠道菌群变化。结果治疗后益生菌组较中药组、对照组CD3+、CD4+、CD4+/CD8+比例上升、大便SIgA水平升高(P<0.05),且双歧杆菌/大肠杆菌比例增加(P<0.05)。结论益生菌加中药治疗较单用中药治疗可增强细胞免疫功能,有效改善大肠癌辅助化疗期脾虚证患者肠道菌群失调。Objective To investigate the effects of probiotics on intestinal flora and immune function in postoperative colorectal cancer patients with spleen deficiency.Methods Sixty postoperative colorectal cancer patients,diagnosed as spleen deficiency according to Traditional Chinese Medicine（TCM）,were randomized into probiotics（Bifico）,traditional Chinese drug and control groups.Patients in all groups were treated with chemotherapy.In addition,for 4 weeks,patients in probiotics group received probiotics（Bifico） plus traditional Chinese drugs,and patients in TCM group received traditional Chinese drugs.In control group patients had no additional treatment.After the treatment,intestinal flora,SIgA in feces and T lymphocytes were evaluated.Results CD4＋,CD3＋ T lymphocytes,CD4＋/CD8＋ ratio,and SIgA in feces were higher in probiotics group than those in the other groups（P0.05）.There were significant differences in Bifidobacterium and Bifidobacterium/Escherichia coli ratio among three groups（P0.05）.Conclusion Probiotics combined with traditional Chinese drugs have better therapeutic effect than traditional Chinese drug used alone in postoperative colorectal cancer patients with spleen deficiency.

关 键 词：化学疗法 辅助 有益菌种 治疗应用 结直肠肿瘤 药物疗法 T淋巴细胞亚群 中西医结合疗法 

分 类 号：R735.34[医药卫生—肿瘤]