姑息放疗联合榄香烯治疗晚期NSCLC的临床疗效观察  

Palliative radiotherapy in combination with Elemene for patients with advanced NSCLC

作　　者：陆忠华[1] 徐珍[1] 汤华[1] 刘景杰[1] 陈玲[1] 

机构地区：[1]苏州大学附属常州肿瘤医院放疗科,江苏常州213002

出　　处：《实用肿瘤杂志》2012年第6期617-619,共3页Journal of Practical Oncology

摘　　要：目的探讨姑息放疗联合榄香烯治疗晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效。方法回顾性分析157例Ⅳ期NSCLC病例,采用姑息放疗联合榄香烯治疗56例,姑息放疗联合姑息化疗35例,吉非替尼靶向治疗39例,单纯姑息放疗27例,运用SPSS 11.0统计软件包分析Ⅳ期NSCLC生存情况。结果姑息放疗联合榄香烯治疗组的患者生存期高于姑息放疗联合姑息化疗组、吉非替尼靶向治疗组、单纯姑息放疗组,有效率分别为96.4%、77.1%、74.4%、66.7%。中位生存期分别为14月、8月、8月、5月(P<0.05),1年生存率分别为71.4%,44.0%,41.8%,21.6%(P=0.000),2年生存率分别为30.4%、2.0%、5.6%、0.0%(P=0.000)。结论姑息放疗联合榄香烯治疗晚期非小细胞肺癌可缓解症状,提高生活质量,延长生存时间。Objective To investigate the efficacy of palliative radiotherapy in combination with Elemene in patients with advanced non-small cell lung cancer（NSCLC）.Methods Clinical data of 157 patients with stage Ⅳ non-small cell lung cancer were retrospectively analyzed.Among them,56 patients received palliative radiotherapy in combination with Elemene,35 received palliative radiotherapy in combination with chemotherapy,39 received target treatment with Gefitinib and 27 received palliative radiotherapy alone,respectively.The survival of patients was analyzed with SPSS 11.0 software.Results For patients receiving palliative radiotherapy in combination with Elemene,palliative radiotherapy in combination with chemotherapy,target treatment with Gefitinib and palliative radiotherapy alone,the effective rates were 96.4%,77.1%,74.4%,66.7%,respectively,（P0.05）.The median survival time（MST） was 14 months,8 months,8 months and 5 months,respectively（P0.05）.One-year overall survival（OS） was 71.4%,44.0%,41.8%,21.6%（P=0.000）,2-year OS,30.4%,2.0%,5.6%,0.0%（P=0.000）,respectively.Conclusion Palliative radiotherapy in combination with Elemene can relieve symptoms,improve survival and the quality of life in patients with advanced non-small cell lung cancer.

关 键 词：癌 非小细胞肺 药物疗法 癌 非小细胞肺 放射疗法 倍半萜类 治疗应用 姑息疗法 存活率 综合疗法 回顾性研究 

分 类 号：R734.2[医药卫生—肿瘤]