甲状腺转录因子-1在晚期非小细胞肺癌中的表达及意义  

Expression of TTF-1 in advanced non-small cell lung cancer and its prognostic significance

作　　者：肖小意[1,2] 戴广海 孙琼[1,2] 石燕 吴倩[1,2] 

机构地区：[1]解放军总医院 [2]解放军医学院肿瘤综合治疗科,北京100853

出　　处：《军医进修学院学报》2012年第12期1293-1295,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的分析甲状腺转录因子-1(TTF-1)在晚期非小细胞肺癌中的表达情况及其预后意义。方法收集解放军总医院2008年6月-2011年6月收住的已行TTF-1检查的晚期非小细胞肺癌患者的临床病理资料,探讨TTF-1与临床病理特征和预后的关系。结果 67例晚期肺鳞癌和腺癌患者中TTF-1的表达与组织学分型表达差异有统计学意义(P<0.05),与性别、年龄、吸烟、TNM分期、组织学分级表达差异无统计学意义(P>0.05)。TTF-1表达阳性的总生存和TTF-1表达阴性的总生存(中位生存时间27.5月vs 29.2月)差异无统计学意义(P=0.546)。结论 TTF-1可用于肺鳞癌及肺腺癌的鉴别诊断;TTF-1表达可能与预后无关。Objective To analyze the TTF-1 expression in patients with advanced non-small cell lung cancer and its prognostic significance. Methods Clinicopathological data were collected from patients with advanced non-small cell lung cancer who underwent TTF-1 in our hospital from June 2008 to June 2011. Relation of TTF-1 expression with clinicopathological features and prognosis of patients with advanced non-small cell lung cancer was studied. Results The TTF-1 expression level and histological classification were significantly higher in 67 patients with squamous cell carcinoma and adenocarcinoma（P〈0.05）. However, no significant difference was observed in gender, age, smoking, TNM staging and histological classification, as well as in overall survival time of patients with positive or negative TTF-1 expression（median survival time 27.5 months vs 29.2 months, P〉0.05）. Conclusion TTF-1 can be used in differential diagnosis of squamous cell carcinoma from adenocarcinoma, but TTF-1 expression may not be related with the prognosis of patients with advanced non-small cell lung cancer.

关 键 词：肺癌 甲状腺转录因子-1 免疫组织化学 预后 

分 类 号：R734.2[医药卫生—肿瘤]