乳腺癌微小钙化灶与C-erbB-2、ER、PR表达的相关性  

Correlation Between Microcalcifications of Breast Cancer and the Expression of C-erbB-2,ER,PR in Breast Carcinoma

作　　者：陆瑶[1] 李青春[2] 方向军[1] 康卯吉[1] 旷野[1] 何卫红[1] 

机构地区：[1]南华大学附属第二医院放射科,湖南衡阳421001 [2]南华大学附属第一医院放射科

出　　处：《中南医学科学杂志》2012年第6期559-562,共4页Medical Science Journal of Central South China

基　　金：衡阳市科学技术局科技发展计划项目基金资助(2011KS27)

摘　　要：目的探讨微小钙化灶的临床价值,评估乳腺癌人类上皮生长因子受体-2(C-erbB-2)、雌激素受体(ER)及孕激素受体(PR)异常表达与微小钙化的相关性。方法回顾性分析经X线检查、手术病理证实的91例乳腺癌患者,评估乳腺微小钙化灶诊断乳腺癌的准确率,按照ACR创立并推荐的BI-RADS,将X线所见钙化征象分为微小钙化组,中间型钙化组,无钙化组进行描述,并与C-erbB-2、ER及PR表达进行对照,分析其相关性。结果乳腺癌微小钙化灶与C-erbB-2的异常表达有显著相关性(P<0.05),而与ER、PR表达无明显相关性。结论乳腺癌微小钙化是其特征性表现,与C-erbB-2表达有一定关联性,可粗略预测C-erbB-2表达情况,并为判断肿瘤生物学行为及患者预后提供一定参考价值。Objective To investigate the value of microcalcifications in breast and to assess the correlation between the malignant microealcifieations of breast cancer and the expression of C-erbB-2,ER,PR in breast carcinoma. Methods A retrospective study of 91 consecutive mammography patients with breast carcinomas was performed to evaluate microealci fications. Each patient was reviewed according to BI-RADS final assessment category system, the calcification was devided into malignant calcification, oseulant calcification and without calcifications. The expression of C-erbB-2, ER and PR was de tected with immunohistoehemical technique in breast cancer. Results The mammographic feature of breast cancer is mi crocalcifications. The C-erbB-2 positive expression was correlated with microcalcifications in breast carcinoma（P 〈0.05）. Conclusion Malignant calcification of the breast carcinoma had a significant correlation with the expression of C-erbB-2. It is feasible to predict the expression of C-erbB-2 in breast carcinoma. So the biological behavior can be assessed by mammo graphic features ,which provide information for prognosis.

关 键 词：乳腺癌 钼靶X线摄影 人类上皮生长因子-2 雌激素受体 孕激素受体 

分 类 号：R737.9[医药卫生—肿瘤]