康复新液联合复合维生素B防治含5-氟尿嘧啶化疗后口腔黏膜炎的疗效观察  

Clinical Observation of Kangfuxin Joint Compound Vitamin B Tablets in Prevention of Oral Mucositis Induced by Chemotherapy Regimen of 5-Fluorouracil

作　　者：陈延群[1] 孙建湘[1] 彭超[2] 

机构地区：[1]南华大学附属南华医院肿瘤科,湖南衡阳421002 [2]南华大学附属第一医院神经内科

出　　处：《中南医学科学杂志》2012年第6期607-609,共3页Medical Science Journal of Central South China

摘　　要：目的观察康复新液联合复合维生素B防治含5-氟尿嘧啶化疗后出现的口腔黏膜炎(oral mucosi-tis,OM)的临床疗效。方法将60例接受含5-氟尿嘧啶化疗的患者回顾性分为治疗组与对照组。治疗组30例于开始化疗第一天配合使用康复新液联合复合维生素B治疗,连用2周;对照组30例于开始化疗第一天配合使用复合维生素B治疗,连用2周。观察疗效时间为治疗开始第一天至结束后。观察两组患者发生OM的分度情况和治疗效果。结果治疗组发生Ⅱ度以上OM的例数明显低于对照组(P<0.05)。治疗组疗效及有效率均明显高于对照组(P<0.05)。结论康复新液联合复合维生素B防治含5-氟尿嘧啶化疗后出现的OM具有明显疗效,能减轻化疗致OM的毒性反应。Objective To observe the clinical effect of Kangfuxin joint Compound Vitamin B tablets in prevention of oral mucositis induced by chemotherapy regimen of 5-Fluorouracil. Methods Sixty patients with chemotherapy regimen of 5-Fluorouracil were divided into treatment group and control group, with 30 in each group. Patients in treatment group were given Kangfuxin joint Compound Vitamin B tablets in addition to routine chemotherapy for two weeks, while the pa- tients in control group were given Compound Vitamin B tablets only. Results The control group showed more serious oral mucositis than the treatment group ;The total effective rate was 100% in treatment group and 80% in control group（P 〈 0. 05）. Conclusions Kangfuxin joint Compound Vitamin B tablets in treating oral mucositis caused by chemotherapy regimen of 5-Fluorouracil proved to be more effective than the Compound Vitamin B tablets alone.

关 键 词：康复新液 复合维生素B 5-氟尿嘧啶 化疗 口腔黏膜炎 疗效 

分 类 号：R735[医药卫生—肿瘤]