肝硬化患者轻微肝性脑病临床相关危险因素分析  

Risk factors of minimal hepatic encephalopathy in patient with liver cirrhosis

作　　者：石绣江[1] 王月[1] 希尔娜依.阿不都黑力力 范晓棠[1] 马海林[1] 冯娟[1] 孙建[1] 阿丽亚.热哈提 何方平[1] 

机构地区：[1]新疆医科大学第一附属医院肝病科,乌鲁木齐市830054

出　　处：《实用肝脏病杂志》2012年第6期542-544,共3页Journal of Practical Hepatology

基　　金：国家自然科学基金(No.C030107/3076022);新疆维吾尔自治区科技计划项目(No.201141137);新疆医科大学第一附属医院科研奖励基金(No.2011YFY14);新疆重大疾病医学重点实验室-省部共建国家重点实验室培育基地(2010DS890294)

摘　　要：目的评估肝硬化人群中轻微型肝性脑病(MHE)发生的相关因素。方法在121例肝硬化患者,分别进行心理肝性脑病得分(PHES)和临界闪烁频率(CFF)测定,并评估肝功能分级状态。结果在121例肝硬化患者中,检出MHE者70例(57.9%)。性别、受教育程度、肝病病因、肝功能Child-Pugh分级、血浆氨浓度等因素对肝硬化患者发生MHE无统计学意义(P>0.05);经Logistic多因素回归分析,仅发现年龄为MHE发生的危险因素(P=0.041,OR=1.035),而MHE发生与性别、教育程度、肝病病因、肝功能Child-Pugh分级和血浆氨浓度无关(P>0.05)。结论在肝硬化患者中MHE发生率较高,年龄增长是肝硬化患者发生MHE的危险因素。Objective The aim of this study was to assess the morbidity of minimal hepatic encephalopathy （MHE） in patients with liver cirrhosis. Methods 121 patients with liver cirrhosis were selected,and the psychometric hepatic encephalopathy score （PHES）and critical flicker frequency （CFF）were conducted in the series. Results The morbidity of MHE was 57.9% in the 121 patients with liver cirrhosis;the blood ammonia concentra- tion,gender,education,etiology of liver cirrhosis and Child-Pugh scores were not correlated to the incidence of MHE; Multivariate analysis showed that only age was the risk factor of MHE （P=0.041,OR=1.035）. Conclusion MHE is common in patients with liver diseases,which should managed properly.

关 键 词：肝硬化 轻微型肝性脑病 临界闪烁频率 心理肝性脑病得分 

分 类 号：R747.9[医药卫生—神经病学与精神病学]