Bis-GMA/TEGDMA树脂水解产物分析  

Analysis of hydrolysis products of Bis-GMA /TEGDMA resin

作　　者：郝爱连[1] 肖玉鸿[1] 邢晓东[2] 张文云[1] 陈吉华[3] 杨立斗[1] 

机构地区：[1]成都军区昆明总医院口腔科昆明医医科大学教学医院,昆明650032 [2]南京理工大学化工学院,南京210094 [3]第四军医大学口腔医学院修复科,西安710032

出　　处：《口腔材料器械杂志》2012年第4期181-186,共6页Chinese Journal of Dental Materials and Devices

基　　金：国家自然科学基金项目(30973356;81130078)

摘　　要：目的检测Bis-GMA/TEGDMA树脂片经去离子水浸泡后的水解产物。方法 Bis-GMA/TEGDMA单体加入CQ/DMAEMA后光照聚合制备树脂片,将树脂片经37℃恒温去离子水浸泡24 h,其中在1h、3 h、6 h和24 h四个时间点各取1 mL浸泡液,用乙酸乙酯萃取、旋蒸,通过高效液相色谱质谱法(HPLC/MS)检测分析,确定树脂水解产物。结果树脂片的水解产物为双酚A-二甘油醚(Bis-GMA-2MA)、双酚A-二氧代丙基醚(Bis-GMA-2MA-2H2O)、单甲基丙烯酸二缩三乙二醇酯(TEGDMA-MA)和二缩三乙二醇(TEGDMA-2MA)。结论 Bis-GMA/TEGDMA树脂片经去离子水浸泡后树脂可发生水解,水解产物及残余Bis-GMA/TEGDMA树脂单体可析出并释放到去离子水中。Objective To detect the hydrolysis products of resin discs immersed in demonized water. Methods Light-cured resin discs composed of Bis-GMA/TEGDMA and CQ/DMAEMA were immersed in deionized water for 24 h at 37℃, then, 1 mL of soak Solution at 1 h, 3 h, 6 h and 24 h was extracted with ethyl acetate and evaporated by a rotary evaporator. Finally the hydrolysis products of resins were confirmed through the high performance liquid chromatography （HPLC） and mass spectrometry （MS）. Results The hydrolysis products of Bis-GMA/TEGDMA resin discs were Bis- GMA-2MA, Bis-GMA-2MA-2H20, TEGDMA-MA and TEGDMA-2MA, respectively. Conclusions Bis-GMA/TEGDMA resin was hydrolyzed after immersed in deionized water. The hydrolysis products and residual monomers of Bis-GMA/ TEGDMA could be released into deionized water.

关 键 词：Bis—GMA TEGDMA树脂 水解 高效液相色谱质谱 

分 类 号：R783.1[医药卫生—口腔医学]