心脏原发肿瘤81例临床病理分析  

Primary cardiac neoplasms： a clinicopathologic analysis of 81 cases

作　　者：王继纲[1] 刘晖[1] 于文娟[1] 李玉军[1] 信芳杰[1] 

机构地区：[1]青岛大学医学院附属医院病理科,266003

出　　处：《中华病理学杂志》2012年第12期808-812,共5页Chinese Journal of Pathology

摘　　要：目的分析一个区域医疗中心连续8年的原发心脏肿瘤，以期提高对该类疾病的认识。方法回顾性研究2004年1月至2011年12月8年间在青岛大学医学院附属医院心外科接受手术或病理科会诊、并有完整临床及病理资料的81例心脏原发肿瘤病例。通过复习存档病案获得临床资料；通过查阅病理数据库收集病理资料，并重新复习大体检查记录及HE切片，对部分病例进行免疫组织化学染色。结果81例病例中良性肿瘤73例（90．1％，73／81），恶性肿瘤8例（9．9％，8／81）。心脏黏液瘤约占良性肿瘤的97．3％（71／73），8例恶性肿瘤中6例为软组织肉瘤。具体组织学类型为：黏液瘤71例，血管肉瘤2例，恶性纤维组织细胞瘤2例，淋巴瘤2例，血管瘤1例，乳头状纤维弹力瘤1例，黏液性纤维肉瘤1例，脂肪肉瘤1例。心脏原发肿瘤的常见症状为胸闷憋气。结论心脏原发肿瘤中黏液瘤占绝大多数，也有其他类型的肿瘤。正确的诊断和及时的手术治疗非常重要。Objective To study the disease spectrum, clinical and pathologic features of primary cardiac neoplasms at a single medical institution during a period of eight years. Methods The clinical and pathologic features of 81 cases of primary cardiac neoplasms encountered at the Affiliated Hospital of Medical College, Qingdao University from January, 2004 to December, 2011, either for cardiovascular surgery or as pathology consultation cases, were retrospectively reviewed. Immunohistoehemical study was carried out in selected examples. Results Amongst the 81 cases studied, 73 cases （90. 1% ） were benign and 8 cases （9. 9% ） were malignant. Cardiac myxomas accounted for 97.3% （71/73） of all the benign cases. Six of the 8 malignant cases represented soft tissue sarcomas. The commonest presenting symptom was dyspnea. The histologic subtypes included myxoma （ number = 71 ）, angiosareoma （ number = 2 ）, malignant fibrous histiocytoma （ number = 2 ）, hemangioma （ number = 1 ）, liposarcoma （ number = 1 ）, lymphoma （ number = 1 ）, myxofibrosarcoma （ number = 1 ） and papillary fibroelastoma （ number = 1 ）. Conclusions While the majority of primary cardiac neoplasms are myxomas, other tumor types do exist. Accurate histologie diagnosis and timely surgery are crucial in patient management.

关 键 词：心脏肿瘤 病理学 临床 粘液瘤 

分 类 号：R732.1[医药卫生—肿瘤]