白内障患者Lenstar与A型超声或角膜曲率计眼部生物学参数测量结果的比较  

Comparison of the biometric measuring outcomes between Lenstar and A-scan ultrasound biometry or keratometer in cataract patient

作　　者：沈政伟[1] 尹禾[1] 薛林平[1] 姜黎[1] 刘洪[1] 李丽[1] 吴金桃[1] 

机构地区：[1]广州军区武汉总医院眼科医院,武汉430070

出　　处：《中华实验眼科杂志》2012年第12期1114-1117,共4页Chinese Journal Of Experimental Ophthalmology

摘　　要：背景精确的眼部生物学参数对眼科疾病的诊断、治疗及预后有着重要的意义，筛选简便、准确测量眼部生物学参数的方法至关重要。目的比较LenstarLS900型光学生物测量仪与A型超声或角膜曲率计在测量眼轴长度、角膜曲率（K1、K2、Km）以及预测人工晶状体（IOL）度数方面的差异，为Lenstar光学生物测量仪的临床应用提供依据。方法共纳入年龄相关性白内障患者40例43眼，分别应用Lenstar、A型超声法或角膜曲率计测量受检眼眼轴长度及K1、K2、Km值，计算IOL度数。采用配对t检验对两种测量结果的差异进行比较，两种方法测量结果的一致性评价采用Bland—Ahamn分析。结果共有35眼完成测量。Lenstar与A型超声测量的眼轴长度分别为（23．3414-1．208）mm和（23．2684-1．157）mm，二者比较差异无统计学意义（t=0．260，P=0．796）。Lenstar与角膜曲率计测量Kl、K2、Km值的差异均无统计学意义（t=0．526，P=0．601；t：0．927，P=0．357；t=0．213，P=0．832）。两种方法预测的IOL度数分别为（20．3714-2．827）D和（20．729±2．672）D，二者比较差异无统计学意义（t=0．543，P=0．589）。Bland-Altamn一致性检验表明，Lenstar与A型超声或角膜曲率计测量的眼轴长度，K1、K2、Km值以及IOL度数分别有11％（4／35）、0％（0／100）、9％（3／35）、9％（3／35）、6％（2／35）的点位于95％的一致性界限以外，在一致性界限内最大差值的绝对值为0．39mm和1．31、1．30、0．77、1．00D。结论Lenstar能够检测多种测量指标，测量过程具有非侵人性、方便快捷、用时较短等优点，但本研究的结果认为Lenstar与A型超声或角膜曲率计的方法一致性不好，二者是否可以互相替代还需要进一步的大样本临床研究证实。Background The accuracy of biometric measurement is critical for precise diagnoses and prognosis evaluation of ocular diseases. Objective The present study was to evaluate the differences of Lenstar with A-scan ultrasound biometry or keratometer in ocular bio-measurement. Methods Written informed consent was obtained from each subject before examination. Total 43 eyes of 40 age-related cataract patients were enrolled in this study. Axial length, corneal curvature（ K1, K2, Km）and intraocular lens （IOL）power were measured with Lenstar, A-scan ultrasound biometry and keratometer, separately. The differences of measuring outcomes were compared between these two methods according to a paired samples t test, and the agreement analysis of measuring outcomes between Lenstar and A-scan ultrasound biometry or keratometer was performed by Blant-Ahman plots. Results Thirty-five eyes finished the clinical bio-measurement. The axial length was （ 23. 341 _＋ 1. 208 ） mm and （ 23. 268 -＋ 1. 157）mm based on Lenstar method and A-scan ultrasound biometry method, respectively, with a insignificant difference between them （ t = 0. 260, P = 0. 796）. No significant differences were found in the KI, K2 and Km values between Lenstar and keratometer methods （ t = 0. 526, P = 0. 601 ; t = 0. 927, P = 0. 357 ; t = 0. 213, P = 0. 832 ）. The IOL power was （ 20.371 _＋2. 827 ） D and （ 20. 729 ＋ 2. 672 ） D, respectively in Lenstar method and keratometer method, without statistically significant difference between them （ t = 0. 543, P = 0. 589 ）. Bland-Ahamn agreement analysis showed that the dots of 11% （4/35）,0% （0/100）,9%（3/35）,9% （3/35）,6% （2/35） were out of 95% confidence limit, and the absolute values of maximal difference value between Lenstar and A-scan ultrasound biometry or keratometer methods was 0.39 mm, 1.31 D, 1.30 D,0.77 D and 1.00 D in ocular axial length, K1 , K2 and Km values and IOL power, respectively. Conclusions As a new bio-measuring method, Lenstar can offer mu

关 键 词：生物测量 Lenstar生物测量仪 A型超声 角膜曲率计 眼轴长度 角膜曲率 人工晶状 体 白内障 

分 类 号：R779.66[医药卫生—眼科]