β-钛合金在犬前喉裂开治疗中的初步研究  

Replacement of a anterior larynx split with a β-type titanium alloy prosthesis in subglottic stenosis :a preliminary study in canine

作　　者：谭爱兴 成诗银[2] 崔鹏程[2] 高鹏飞[2] 

机构地区：[1]解放军第537医院耳鼻咽喉科,陕西宝鸡721000 [2]第四军医大学唐都医院耳鼻咽喉科,陕西西安710038

出　　处：《现代肿瘤医学》2012年第12期2486-2488,共3页Journal of Modern Oncology

摘　　要：目的:通过应用新型的多孔介稳定β型钛合金(TLM)对犬的喉气管软骨缺损的修复,以评估该材料对声门下狭窄治疗的有效性。方法:取5只犬,将犬的喉与气管充分暴露,切除环状软骨及第1气管软骨环的前1/3形成喉前裂开,将"◇"形的生物材料替代切除的部分喉气管组织,按设计于术后3至6个月对受试动物进行气管镜检测。结果:术后所有受试犬均未见任何气道阻塞。未见修复体的移位暴露,内表面无肉芽组织生长及吻合口裂开。结论:该材料是一种很有潜力的新型喉气管缺损的修复材料,值得进一步更大部分喉气管缺损修复的研究。Objective：To explore the efficacy of a new meta-stable β-type titanium alloys（TLM） in a canine cricoid and trachea for the treatment of laryngotracheal stenosis.Methods： Porous TLM alloy was used as a tissue scaffold for airway regeneration in five dogs.The larynx and the trachea were exposed.The anterior 1/3 part of the cricoid cartilage（cover the cricothyroid membrane） and 1 cervical trachea were simultaneously resected by cold instruments form an artificial anterior larynx open.The ＂◇＂ scaffold material was implanted into the resultant defect.Endoscopic examination was undertaken periodically for a postoperative period of three to six months in all dogs.Results： Endoscopic examination showed the implant located perfectly and the airway was wide enough for breath.There was no airway stenosis in any dogs.Granulation was observed in no cases,and anastomotic dehiscence was not observed.Conclusion： It was a promising new type material to repair the laryngotracheal defect,and it was worthy of further research for repair of a larger part laryngotracheal defects.

关 键 词：TLM 声门下狭窄 喉气管重建 犬 

分 类 号：R739.65[医药卫生—肿瘤]