肝癌患者无水酒精治疗前后外周血IL-6、TGF-β_1的变化  

Changes of IL-6,TGF-β_1 before and after the therapy of percutaneous ethanol injection in patients with hepatocellular carcinoma

作　　者：栾玉爽[1] 李航[2] 赵盛发[2] 杨伟萍[2] 丁战玲[2] 李想[2] 

机构地区：[1]航空总医院,北京100021 [2]广西医科大学附属肿瘤医院

出　　处：《山东医药》2012年第40期8-10,共3页Shandong Medical Journal

基　　金：广西自然科学基金资助项目(桂科0832228)

摘　　要：目的监测超声引导下经皮无水酒精注射术(PEI)治疗前、后肝细胞癌患者外周血中细胞因子白介素6(IL-6)、转化生长因子β1(TGF-β1)的动态变化,分析PEI治疗对患者机体免疫功能的影响。方法采用酶联免疫吸附法检测30例原发性肝癌患者在PEI治疗前和治疗3次、6次、8次后IL-6、TGF-β1的改变,并与健康对照组比较。结果 PEI治疗前IL-6、TGF-β1高于对照组(P<0.01)。IL-6、TGF-β1PEI治疗3次后较治疗前升高(P<0.05);治疗6次后均降低到治疗前水平;治疗8次后IL-6继续下降,但与治疗前比较差异无统计学意义(P>0.05),而TGF-β1较治疗前降低明显(P<0.05)。结论 PEI能有效杀死肿瘤细胞,降低肿瘤负荷,增加机体的免疫功能。但PEI早期可能会导致机体出现短期的免疫抑制。Objective To analyze the effects of ultrasound-guided percutaneous ethanol injection （PEI） on immune function of patients with hepatocellular carcinoma （HCC） by monitoring the changes of IL-6, TGF-β1 before and after PEI. Method Enzyme linked immunosorbent assay （ELISA） was used to measure the immune state of 30 patients with primary hepatic carcinoma （PHC） respectively before PEI and at the 3rd, 6th, 8th treatment of PEI, and compared with health controls. Results Before PEI, IL-6 and TGF-β1 significantly increased in patients with PHC as compared with those in normal individuals （P 〈 0.01 ）. The levels of IL-6 and TGF-β1 after 3rd treatment were significently higher than those before PEI （P 〈 0.05 ）, and both rapidly reduced to pretherapy level after 6th treatment. After 8th treament, IL-6 reduced but had no significant difference from that before PEI （ P 〉 0.05 ）, but TGF-β1 reduced significantly and was lower than that before PEI statistically （ P 〈 0.05 ）. Conclusions PEI can effectively kill tumor ceils, reduce the tumor burden, and increase immune function. But PEI may cause a transient immune suppression at the early therapy.

关 键 词：癌 肝细胞 经皮无水酒精注射术 白介素6 转化生长因子Β1 

分 类 号：R735.7[医药卫生—肿瘤]