急性脑梗死与CRP启动子区-717A／G多态性及CRP水平相关性探讨  

Research on the correlation between acute cerebral infarction with the -717A/G functional polymorphism of CRP and CRP

作　　者：冯涛[1] 徐秀芝[1] 杨勇[1] 王晓敏[1] 祝鸿雁[1] 许晓崴[1] 

机构地区：[1]黑龙江省医院神经内二科,黑龙江哈尔滨150001

出　　处：《中国急救医学》2012年第12期1080-1082,共3页Chinese Journal of Critical Care Medicine

基　　金：黑龙江省科技厅青年基金项目（QC2009C104）

摘　　要：目的分析急性脑梗死与C-反应蛋白（CRP）水平及其启动子区-717A／G多态性的关系。方法采用免疫比浊法测定125例急性脑梗死患者和130例健康对照者的血清CRP水平，同时应用PCR-RFLP方法检测CRP-717A／G基因多态性，结合其他临床资料进行分析。结果含有AA型与AG型个体的血清CRP水平明显高于GG型个体，病例组与对照组收缩压、舒张压、血糖、CRP、纤维蛋白原、甘油三脂、胆固醇及血细胞比容差异有统计学意义。结论急性脑梗死患者中-717A／G位点A等位基因可能有增加CRP水平的趋势，CRP、胆固醇、纤维蛋白原、血糖、年龄及收缩压等因素对急性脑梗死有直接作用。Objective To study the relationships between acute cerebral infarction with C - reactive protein level and the -717A/G functional polymorphism of CRP promoter. Methods The polymerase chain reaction - restriction fragment length polymorphism （PCR - RFLP） was used to determine the CRP gene polymorphism in 125 patients with acute cerebral infarction and 130 controls and analyze these combined with clinical manifestations. Results Statistical analysis showed that the average level of CRP was higher in the AA and AG genotypic subjects than that in the GG genotypic subjects. Researchers also identified the following acute cerebral infarction inducing factors, which were ranked by the degree of correlation： CRP, cholesterol, blood glucose, fibrinogen, age and Systolic blood pressure. Conclusion There is significant relationship between the -717A/G functional polymorphism of CRP promoter with CRP protein level and the acute cerebral infarction. CRP, cholesterol, fibrinogen, blood glucose, age and systolic blood pressure are all risk factors of the acute cerebral infarction disease.

关 键 词：急性脑梗死 C-反应蛋白(CRP) 基因多态性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]