^18F-FDG PET-CT在霍奇金淋巴瘤疗效评价中的临床价值  

A preliminary study on clinical value of ^18F-FDG PET-CT in evaluation of efficacy of Hodgkin lymphoma

作　　者：林端瑜[1] 唐明灯[1] 李生栩[1] 刘道佳[1] 张杰平[1] 蔡志华[1] 

机构地区：[1]福建省肿瘤医院核医学科,福州350014

出　　处：《国际放射医学核医学杂志》2012年第6期352-357,共6页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的探讨^18F-FDG PET-CT在霍奇金淋巴瘤（HL）疗效评价中的临床价值。方法回顾性分析31例HL患者化疗后的^18F-FDG PET-CT图像资料，最终结果经病理和临床随访证实，并与治疗后单纯CT结果进行对比分析，采用四格表r进行差异的显著性检验。结果①31例患者共发现病灶145处，其中恶性94处、良性51处。^18F．FDG PET-CT评价HL治疗效果的灵敏度、特异度、阳性预测值、阴性预测值及准确率分别为97．87％、94．12％、96．84％、96．00％和96．55％，均明显优于单纯CT检查（Х^2=9．83、13．49、11．50、11．69、22．58，P均〈0．05）。②31例患者经PET—CT显像后，16例（51．61％）更改治疗方案。结论^18F—FDG PET-CT是HL疗效监测的有效手段。Objective To explore the clinical value of lSF-FDG PET-CT in the evaluation of efficacy of Hodgkin lymphoma （HL）. Methods Thirty-one cases of post-treatment patients with HL were studied retrospectively, lSF-FDG PET-CT images after chemotherapy were compared with CT post-therapy results. The final diagnosis was based on pathology or clinical follow-ups. Results ①A total of 94 malignant lesions and 51 benign lesions were found in 31 patients in the study. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ^18F-FDG PET-CT in the evaluation of efficacy of HL were 97.87%, 94.12%, 96.84%, 96.00% and 96.55% respectively, which were significantly superior to CT examination alone （X^=9.83, 13.49, 11.50, 11.69, 22.58, all P〈0.05）. ②According to the results of PET-CT, therapeutic schedules of 16 cases （51.61%）had been changed. Conclusion ^18F-FDG PET-CT is an effective method in the evaluation of efficacy of HL.

关 键 词：霍奇金病 治疗效果 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术X线计算机 

分 类 号：R730.44[医药卫生—肿瘤]