太子参多糖对糖尿病小鼠抗氧化能力与胰腺病理的影响  

Effect of Pseudostellaria heterophylla polysaccharides on anti-oxidation capacity and pancreatic pathology of diabetic mouse

作　　者：徐先祥[1] 黄玉香[1] 夏伦祝[2] 张睿[2] 

机构地区：[1]华侨大学生物医学学院,福建泉州362021 [2]安徽省中医院药学部,安徽合肥230031

出　　处：《食品工业科技》2012年第24期392-393,共2页Science and Technology of Food Industry

基　　金：安徽省教育厅自然科学研究项目(2004KJ258)

摘　　要：目的:观察太子参多糖对糖尿病小鼠的抗氧化功能和胰腺形态的影响。方法:雄性小鼠,尾静脉注射四氧嘧啶90mg/kg建立小鼠糖尿病模型,太子参多糖按0.375、0.75、1.5g/kg三种剂量给药,测定小鼠血清超氧化物歧化酶(SOD)水平和丙二醛(MDA)含量,观察胰腺病理组织学变化。结果:太子参多糖能显著提高实验性糖尿病小鼠血清SOD水平,降低MDA含量,减轻胰腺病理组织学变化。结论:太子参多糖能明显改善糖尿病小鼠抗氧化功能,保护胰腺。Objective：To observe effect of Pseudostellaria heterophylla polysaccharides on anti-oxidation capacity and pancreatic pathology diabetic rats. Methods=The experimental diabetic mice model were established by alloxan 90mg/kg iv, Pseudostellaria heterophylla polysaccharides were administered at the doses of 0.375, 0.75,1.5g/kg for 3 weeks. The serum superoxidedismutase（SOD） activities and malondialdehyde（MDA） contents were determined and the pancreatic pathology was observed microscopically. Results：Pseudostellaria heterophylla polysaccharides could sgnificanty increase SOD activities and decrease MDA contents. The pathological damage, in diabetic mice was alleviated. Conclusion.Pseudostellaria heterophylla polysaccharides could probably improve anti-oxidation capacity and pancreatic pathology in diabetic mice.

关 键 词：太子参多糖 糖尿病 抗氧化 胰腺 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]