小剂量双氯灭痛、透明质酸混合凝胶减轻复发性阿弗它口疮疼痛的随机双盲临床试验  

SMALL DOSE DICLOFENAC DELIVERED IN HYALURONAN RELIEVES ORAL APHTHOUS ULCER PAIN—— A RANDOMIZED, DOUBLE-BLIND CLINICAL TRIAL

作　　者：姜军松[1] 吕兴标[1] 孙元斌 潘震亚 华柏春 

机构地区：[1]浙江湖州市解放军98医院,浙江313000

出　　处：《中国疼痛医学杂志》2000年第2期89-91,共3页Chinese Journal of Pain Medicine

摘　　要：目的 :验证 3%双氯灭痛、2 .5 %透明质酸混合凝胶能减轻复发性阿弗它口疮(RAU)疼痛的假设。方法 :采用随机双盲对照临床试验 ,对 6 0例未伴有系统性疾病的RAU病人进行单一剂量研究 ,分为三个治疗组 :3%双氯灭痛与 2 .5 %透明质酸混合凝胶组 ,2 .5 %透明质酸凝胶组 ,3%利多卡因凝胶组。治疗前与治疗后 1至 8小时作视觉模拟评分法 (VAS)疼痛评分。结果 :治疗后 2至 6小时区间 3%双氯灭痛与2 .5 %透明质酸凝胶联合应用组能使原有疼痛减轻 5 0 %～ 73% ,与治疗前比较 ,统计学差异显著 (P <0 .0 5 ) ;而同一时间单剂透明质酸凝胶以及利多卡因凝胶VAS评分与治疗前相比无统计学差异。结论 :3%双氯灭痛与 2 .5 %透明质酸混合凝胶是有效减少复发性阿弗它口疮疼痛的治疗方法。Aim: To test the hypothesis that topically applied 3% diclofenac in 2.5% hyaluronan reduces aphthous ulcer pain. Methods: A randomized, double blind, single dose study was undertaker in 60 otherwise healthy adults with aphthous ulcers in three treatment groups:3% diclofenac in 2.5% hyaluronan, 2.5% hyaluronan and 3% viscous lidocaine. Visual analogue scale pain scores were obtained before and after gel application hourly, for up to 8 hours after gel application. Results: A 50% to 73% pain reduction (P<0.05)was reported 2 to 6 hours after the application of diclofenac in hyaluronan,whereas hyaluronan gel alone and viscous lidocaine failed to produce significant VAS reductions. Conclusions: A dose of 3% diclofenac in 2.5% hyaluronan is an effective and novel treatment for this common,painful disorder.

关 键 词：阿弗口疮 疼痛 双氯灭痛 透明质酸 

分 类 号：R781.5[医药卫生—口腔医学]