微生物产生的免疫抑制活性化合物S-9818的研究 Ⅱ.发酵及生物学性质  

Study on a streptomyces-produced immunosuppressive-activity compound S-9818 Ⅱ. Fermentation and biological properties

作　　者：吕淑君[1] 张新宜[1] 田敏[1] 

机构地区：[1]四川抗菌素工业研究所,成都610051

出　　处：《中国抗生素杂志》2000年第3期164-166,共3页Chinese Journal of Antibiotics

摘　　要：千佛链霉菌新种 SIIA9818(Streptomycesqianf oensis sp nov SIIA9818)在含合适碳氮源的培养基内 ,经发酵获约 50 %菌丝量的培养液。发酵第 5天 ,其代谢产物 S-9818的产生达到高峰 ,主要存在于菌丝体内。S-9818对革兰氏阳性、阴性菌和酵母不显示抗微生物活性 ,但有显著的抗其它真菌性质 ,特别是对黑曲霉、烟曲霉有极强的抗菌作用。淋巴细胞产生抑制试验显示 ,S-9818比环孢素有更强的抑制小鼠淋巴细胞产生的免疫抑制性能 ,S-9818的生物学性质与日本报道的 FK-50 6十分相似。In a common medium with suitable C, N sources, Streptomyces qianfoensis sp. nov. SIIA 9818 was cultured for 7 days, harvested cultural broth with 50% mycelial mass. A metabolite named S 9818 was obtained in a peak amount at 5th day in the mycelia mainly. S 9818 appeared no activities against G +, G - bacteria, neither yeast, but active against the fungi, Aspergillus niger and A.fumigatus , especially. In the inhibition tests of lymphocyte proliferation in mice, S 9818 demonstrated its immuno inhibiting properties, it has more stronger effects of inhibiting lymphocyte proliferation than those of Cyclosporin A. As for its biological properties, we found that S 9818 is very similar to FK 506, an immunosuppressant developed in Japan.

关 键 词：免疫抑制剂 S-9818 FK-506 发酵 微生物 

分 类 号：R979.5[医药卫生—药品] TQ465.92[医药卫生—药学]