未成熟脑黑质网状系统与癫痫性脑损伤  

The immature brain substantia nigra reticulata structure system and epileptic brain injury

作　　者：卢金英(综述)[1] 郝艳秋(审校)[1] 

机构地区：[1]哈尔滨医科大学附属第二医院儿内科,150086

出　　处：《国际儿科学杂志》2012年第6期576-579,共4页International Journal of Pediatrics

摘　　要：癫疴是由多种病因引起的慢性脑功能障碍综合征，其起病与年龄密切相关，尤其好发于未成熟脑组织。长期反复癫痫发作可导致未成熟脑组织损伤，使未成熟脑对癫痫性脑损伤的易患性增加。脑黑质网状部既有精细的抗痉挛作用，同时又是癫痫发作的易损脑区。根据这一特点保护未成熟脑黑质网状部可以预防或减轻癫痫发作，同时对癫痫性脑损伤的恢复具有重要作用。给予患儿黑质网状部脑保护类药物是治疗癫疴陛脑损伤的有效方法。Epilepsy is a brain dysfunction syndrome resulted from many causes, which is closely related to age, especially occuring in the immature brain. Long-term, repeated seizures can lead to immature brain tissue damage,and increase susceptibility of immature brain to epileptic brain damage. Not only does substantia nigra network have the effect of delicate anticonvulsion,but it is also vulnerable to epileptic seizures. Protecting the im- mature brain substantia nigra pars can prevent or reduce the risk of seizures, epilepsy has an important role in brain injury recovery. Giving children the brain protective drugs aimed directly at substantia nigra pars is a viable and effective method to treat epileptic brain injury.

关 键 词：癫疴 未成熟脑 黑质网状部 脑损伤 脑保护 

分 类 号：R742.1[医药卫生—神经病学与精神病学]