膀胱癌与P16基因缺失关系的探讨  

The deletions of P16 gene detected in bladder cancer by duplex PCR

作　　者：李泽惠[1] 许绍斌[2] 郭萍[3] 石勇刚[4] 章宗籍[3] 褚嘉祐 

机构地区：[1]昆明医学院附属第二医院泌尿外科,昆明650101 [2]中国医学科学院医学生物研究所遗传室 [3]昆明医学院病理教研室 [4]昆明医学院附属第一医院泌尿外科

出　　处：《临床泌尿外科杂志》2000年第6期271-272,共2页Journal of Clinical Urology

摘　　要：目的 :探讨膀胱癌的发生与 P16基因缺失的关系。方法 :采用双重 PCR法对 31例膀胱癌组织中 P16基因进行检测。结果 :31例膀胱癌组织中有 7例存在 P16基因缺失 ,缺失率为 2 2 .6 %。结论Purpose:To investigate the deletion of P16 g ene in the bladder cancer.Methods:The P16 gene was analysi s by duplex PCR in 31 bladder cancer tissue samples.Results:The gene deletions were found in seven samples.The deletion ratio of P16 gene was 22.6 per cent.Five cases had deletion in exon 2. One case had deletion in exon 1 and one had deletion in both exon 1 and exon 2.Conclusions:The results suggest that the deletion of P16 gene were associated with some bladder cancer.

关 键 词：膀胱肿瘤 聚合酶链反应 基因缺失 P16基因 

分 类 号：R737.140.2[医药卫生—肿瘤]