多孔掺锶羟基磷灰石陶瓷制备及其生物学性能研究  

Synthesis of Strontium-containing Porous Hydroxyaptite Ceramics and Study of Its Biological Properties

作　　者：邹文[1,2] 冉旭[3] 梁洁[1,2] 陈和仲[1] 罗教明[1] 

机构地区：[1]四川大学国家生物医学材料工程技术研究中心,成都610064 [2]四川医疗器械生物材料和制品检验中心,成都610064 [3]四川大学轻纺与食品学院,成都610064

出　　处：《生物医学工程学杂志》2012年第6期1131-1137,共7页Journal of Biomedical Engineering

基　　金：四川大学青年教师科研启动基金资助项目(2009SCU11065)

摘　　要：羟基磷灰石掺锶具有优化材料生物学及理化性能的作用,而由掺锶导致材料组织学反应的机理有待开展进一步的研究。将微波等离子方法制备的4种不同锶含量的掺锶羟基磷灰石(Sr-HA)陶瓷植入实验狗肌肉中,观察其肌肉内组织学反应,样品中掺锶量分别为0、1、5、7mol%。植入周期分别为4、8和12周。在12周时,组织学观察结果显示,在掺锶5mol%以下时,刺激反应轻度,而且掺锶5mol%的植入样品周围有较多的骨组织存在,掺锶量7mol%的羟基磷灰石陶瓷对肌组织有害,减少了诱导成骨的量。锶含量为5%时,组织反应轻度而且诱导生成的新骨组织生长良好,可考虑应用于临床。Strontium added into porous hydroxyaptite ceramics has the functions of improving its osseointegration, decreasing its dissolution rate and improving the bone density. Strontium-containing hydroxyaptite （Sr-HA） ceramics has been used as bone replacement and scaffold to treat the osteoporosis and bone default in clinic, but the mechanism of interracial tissue response caused by the trace element Sr in St-HA ceramics still remains to be further studied. Four types of Sr-HA ceramic samples with different contents of Sr were prepared by microwave plasma sintering for testing the response of the soft tissue implanted in dog muscles in our laboratory. The contents of Sr element in the samples are 0mol%,lmol%, 5moil, and mol% ,respectively. The samples were implanted in the muscle of the dogs for 4 weeks, 8 weeks and 12 weeks, respectively. The histological observations at the end of each period showed that the irritant ranking increased with the content of Sr in St-HA ceramics at the end of 12 weeks, and there were rich bone tissue in Sr-HA ceramic samples with 5mol%Sr element. The overdose of element Sr is harmful to soft tissues. When the content of Sr in Sr-HA ceramic was below 5mol%, the soft tissue response was very and the new bones were induced to grow well.

关 键 词：掺锶羟基磷灰石 微波等离子烧结 纳米陶瓷 肌内植入 刺激反应 

分 类 号：R318.08[医药卫生—生物医学工程]