江浙沪地区HLA-DQB1基因对重症肌无力的遗传易感性研究  

Study on HLA-DQB1 polymorphism to myasthenia gravis susceptibility in Chinese Jiangzhehu areas

作　　者：杜可明[1] 张可雄[2] 陈秀珍[2] 左及[2] 夏培莉 吕传真[3] 郝中顺[3] 

机构地区：[1]山东省泰山医学院医学遗传学教研室,泰安271000 [2]上海医科大学医学遗传学教研室,上海200032 [3]上海医科大学华山医院神经内科,上海200040

出　　处：《中国免疫学杂志》2000年第6期297-299,共3页Chinese Journal of Immunology

基　　金：国家青年自然科学基金资助!(No.39500049)

摘　　要：目的 :探讨中国汉人MG易感性与HLA DQB1基因多态性的相关性。方法 :运用PCR RFLP法进行HLA DQB1基因分型。结果 :MG病例组 (包括亚组 )与对照组比较都有DQB1 0 30 3频率的明显增高 ,DQB1 0 6 0 1和DQB1 0 6 0 2频率的明显降低 ,差异都有显著性。结论 :DQB1 0 30 3参与中国汉人MG的易感性 ,而DQB1 0 6 0 1和DQB1 0 6 0Objective:Analyze the association HLADQB1 gene polymorphism and MG susceptibility in Chinese Hans. Methods:HLADQB1 were genetyped using PCRRFLP. Results:Compared the frequency of HLADQB1 alleles between MG patients (included subgroups) and the healthy controls. The frequency of DQB1*0303 was significantly increased,and the frequency of DQB1*0601 and DQB1*0602 was significantly decreased. The differences were statisticaly. Conclusion:DQB1*0303 was susceptible to MG in Chinese Hans. DQB1*0601and DQB1*0602 were protective genes.

关 键 词：重症肌无力 HLA-DQB1 基因多态性 遗传易感性 

分 类 号：R746.1[医药卫生—神经病学与精神病学]