肢体恶性黑色素瘤的肢体隔离热灌注化疗  

Isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities

作　　者：李晶[1] 王平 朱小军[1] 宋金纲 宋建民[1] 

机构地区：[1]甘肃省肿瘤医院骨与软组织肿瘤科,兰州730050 [2]解放军第二五四医院骨科

出　　处：《中华肿瘤杂志》2012年第12期937-939,共3页Chinese Journal of Oncology

摘　　要：目的探讨肢体隔离热灌注化疗术在肢体恶性黑色素瘤中的治疗效果。方法对41例肢体恶性黑色素瘤患者行肢体隔离热灌注化疗术，术后14～21d对有原发病灶的24例患者行原发病灶切除术，术后病理学检查评价肿瘤坏死情况。结果41例患者中，随访40例，失访1例，随访时间为6—113个月，无一例患者出现局部复发。全组患者的3年和5年生存率分别为95．0％和70．0％。灌注后，肿瘤平均缩小55．6％，术后病理学检查肿瘤坏死率为90％～100％者21例（87．5％），60％-89％者3例（12．5％）。结论肢体隔离热灌注化疗术是治疗肢体恶性黑色素瘤的有效方法，能显著降低局部复发率，提高长期生存率，改善患者的预后。Objective To investigate the effect of isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities. Methods Limb isolated hyperthermic perfusion chemotherapy was performed in 41 patients with malignant melanoma of the extremities, and then the primary lesions in 24 patients were removed at 14-21 days after chemotherapy. Tumor necrosis was examined by pathology. Results Among the 41 patients, 40 cases were followed up for 6-113 months, and one was lost. There was no local recurrence in those patients. 29 cases were followed up for more than 3 years, and 26 of them were surviving. Forteen cases were followed up for more than five years, among them 9 cases were surviving. The 3-year and 5-year survival rates of the whole group were 95.0% and 70.0%, respectively. The average reduction of the tumor volume was 55.6% after perfusion. The pathological examination showed that tumor necrosis was 90% -100% （ complete response） in 21 cases （ 87.5% ） and 60% -89% （ partial response） in 3 cases （ 12.5% ）. Conclusions The isolated limb hyperthermic perfusion chemotherapy is an effective treatment of limb malignant melanoma. It can significantly reduce the local recurrence rate, and improve the 5-year survival rate, prognosis and the quality of life of the patients.

关 键 词：黑色素瘤 四肢 热灌注 药物疗法 预后 

分 类 号：R739.5[医药卫生—肿瘤]