脑梗塞患者血浆β-内啡肽及血清MDA、SOD的变化  

The change of plasma β-EP and serum MDA, SOD in patients with cerebral infarction

作　　者：马琳[1] 张丽娥[1] 刘勇[2] 焦帼范何娅 郑纯礼[3] 张东芳 

机构地区：[1]西安交通大学第二医院老年病科,西安710004 [2]西安交通大学神经生物学研究中心 [3]西安交通大学第二医院儿科实验室 [4]西安交通大学教务处

出　　处：《西安医科大学学报》2000年第3期237-238,共2页Journal of Xi'an Medical University(Chinese)

摘　　要：目的　探讨 β-内啡肽在缺血性脑损伤中的作用机制。方法　应用放射免疫分析法对 46例急性脑梗塞患者血浆β-内啡肽 (β- EP)及血清丙二醛 (MDA)、超氧化物歧化酶 (SOD)含量进行测定。结果　梗塞急性期 β- EP及 MDA、SOD含量均显著升高 (P <0 .0 1 ) ,病情越重 ,含量越高 ;而且血浆β- EP与 MDA含量呈显著正相关 (P <0 .0 1 ) ,β- EP与 SOD含量 ,在轻型病人相关性不明显 ,在中型和重型病人呈显著正相关 (P <0 .0 1 ,P <0 .0 5)。结论　内源性阿片肽和自由基在缺血性脑损伤中具有重要的作用 。Objective To study the mechanism of β Endorphin(β EP) after cerebral infarction.Methods The plasma levels of β EP and the serum levels of malonaldehyde (MDA),superoxide dismutase (SOD) were measured by radioimmunoassay (RIA) in 46 patients with cerebral infarction in the acute stage,compared with those of 30 normal controls.Results The plasma β EP levels and serum MDA, SOD levels were significantly higher in the acute stage of infarction than that of the normal controls(P<0.01).The concentration of plasma β EP and serum MDA,SOD were positively correlated with the severity of neurologic deficits .Meanwhile,the concentration of plasma β EP was positively correlated with the serum of MDA, SOD(P<0 01).Conclusion The endogenous opioid peptides play an important role in the pathogenesis of ischemic cerebral infarction and its mechanism may result from free radicals reaction.

关 键 词：脑梗塞 Β-内啡肽 丙二醛 超氧化物歧化酶 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]