高同型半胱氨酸、高纤维蛋白原等与Binswanger病脑白质疏松严重程度的相关性  

Correlation between severity of leukoaraiosis and plasma levels of homocysteine and fibrinogen in patients with Binswanger disease

作　　者：杨映珊[2] 伍爱民[1] 陆正齐[1] 张炳俊[1] 门雪娇[1] 胡学强[1] 

机构地区：[1]中山大学附属第三医院神经病学科,广州510630 [2]广东省汕头市中心医院中山大学附属汕头医院神经内科工作

出　　处：《中华神经医学杂志》2012年第12期1238-1241,共4页Chinese Journal of Neuromedicine

基　　金：广东省科技计划项目（20118031800255）

摘　　要：目的探讨高同型半胱氨酸（Hcy）、高纤维蛋白g（Fib）等对Binswanger病（BD）IN白质疏松（LA）严重程度的影响。方法对自2005年1月1El至2011年5月9Et在中山大学附属第三医院住院且确诊为BD的患者进行血清Hcy、Fib、低密度脂蛋白（LDL）、载脂蛋白A（Apoa）、载脂蛋白B（Apob）、高密度脂蛋白（HDL）检测，并将BD患者按LA头颅MRI表现严重程度分为轻、中、重3型，单因素分析及有序Logistic回归法分析Fib、Hcy等因素与LA严重程度的关系。结果单因素分析结果显示：LA不同严重程度组间性别、年龄、高血压病、卒中史、高脂血症比较差异有统计学意义（P〈0．05）。LA严重程度与Hcy、Fib存在正向的等级相关关系（P＜0．05）。有序Logistic回归分析结果显示：女性LA程度比男性更严重；年龄越大，有卒中史和Fib测定值越大。LA程度更严重（P＜0．05）。结论Fib水平是BD恶化的一个重要因素，降低Fib水平可能对延缓BD病情进展有效．Objective To investigate the correlation between severity of leukoaraiosis （LA） andplasma levels ofhomocysteine and fibrinogen in patients with Binswanger disease （BD）. Methods All patients with BD, admitted to our hospital from January 2005 to May 2011, were selected consistently with the diagnostic criteria of Bennett. The levels of plasma homocysteine （Hcy）, fibrinogen （Hcy）, low-density lipoprotein （LDL）, apolipoprotein A （Apoa）, apolipoprotein B （Apob）, and high-density lipoprotein （HDL） were measured. According to the Kinkel＇s classification of BD, the severity of LA was graded as mild, moderate, or severe by its appearance under MRI. The relation between levels of plasma Hcy and Fib and severity of LA in BD patients were analyzed. Results Single factor analysis indicated that the dispositions of gender, age, hypertensive disease, stroke and hyperlipoidemia in BD patients with different severities of LA were significantly different （P〈0.05）. The severity degree of LA was positively correlated with the levels of Hcy and Fib （P〈0.05）. Ordered logistic regression analysis showed that female was severer than male in the severity of the LA in BD patients; age, stroke and level of plasma Fib were positively related to the severity of LA in BD patients （P〈0.05）. Conclusion The high plasma level of Fib is an important factor for BD deterioration; reducing the level of plasma Fib may delay the aggravation of BD.

关 键 词：BINSWANGER病 脑白质疏松 纤维蛋白原 同型半胱氨酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]